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Pharm Midterm 2 > Pain > Flashcards

Pain Flashcards

1
Q

What is nociceptive pain

A

Noxious stimuli

Just your regular old pain

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2
Q

What is inflammatory pain

A

Tissue damage present

Still normal

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3
Q

What is neuropathic pain

A

Damage to nervous system

Pathological

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4
Q

What is functional pain

A

Abnormal response to normal stimuli

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5
Q

What is chronic malignant pain

A

Associated with progressive diseases

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6
Q

What is chronic non-malignant pain

A

Not life threatening disease but >6mos past healing period

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7
Q

What kind of pain is acute pain

A

Nociceptive or Neuropathic

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8
Q

Tx of mild pain

A

Non-opiod + adjuvant

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9
Q

Tx moderate pain

A

Medium opioid + Non-opiod + adjuvant

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10
Q

Tx severe pain

A

Strong opioid + Non-opiod + adjuvant

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11
Q

What are the Non-opiods

A

Acetaminophen

NSAIDs

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12
Q

What is the first line for low back pain and OA

A

Acetaminophen

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13
Q

What is a major AE of Acetaminophen

A

Hepatotoxicity

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14
Q

When are NSAIDs given

A

Inflammation pain

RA, Gout

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15
Q

Do Non-opioids have a ceiling

A

Yes

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16
Q

Moderate pain opioids (4-6)

A 
Codeine
Hydrocodone
Oxycodone
Meperidine
Propoxyphene (cept no)
Tramadol
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17
Q

Severe pain opioids (7-10)

A 
Morphine
Hydromorphone
Oxymorphone
Levorphanol
Fentanyl/Sufentanil
Methadone
18
Q

Which Opioids have ceiling

A

Mixed

19
Q

What happens when you go over ceiling

A

Increased chance of AE

20
Q

What are the Mixed

A

Pentazocine
Butorphanol
Nalbuphine
Buprenorphine

21
Q

How is Pruritis/Urticaria managed

A

Hydroxyzine

Diphenhydramine

22
Q

How is constipation managed

A

Senna + Docusate

Laxative + Softener

23
Q

Why are bulk formers not good for pts with advanced disease

A

Needs lots of fluid intake

24
Q

How is N/V managed

A

May become tolerant
Hydroxyzine
Metoclopramide
Prochlorperazine

25
Q

How is Sedation managed

A

Tolerance

Methylphenidate

26
Q

How is Resp Depression managed

A

Naloxone

27
Q

Which opioid is not given via routine dosing

A

Meperidine

Mixed (due to withdrawal and psych)

28
Q

How does routine dosing work

A

Give till comfortable and give again before the effect wears off

29
Q

What is the rescue dose

A

10-20% of daily total requirement - For breakthrough pain (Fentanyl lollipop)

30
Q

When are TCAs given as adjuvants

A

Neuropathic pain
Diabetic neuropathy
Post-herpetic neuralgia
Fibromyalgia

31
Q

What are the TCA AE

A 
Constipation
Xerostomia
Blurred vision
Decreased cognition
Tachy
Orthostatic hypotention --> falls
Weight gain and sedation
32
Q

Which TCAs are secondary amines

A

Desipramine

Nortriptyline

33
Q

Which TCAs are tertiary amines

A

Imipramine

Amitriptyline

34
Q

Which TCAs have less AEs

A

Secondary

35
Q

How do TCAs work

A

NE/5-HT reup inhibitor

Descending inhibition of pain

36
Q

What are the SNRIs

A

Venlafaxine

Duloxetine

37
Q

DOC trigeminal neuralgia pain

A

Carbamazepine

38
Q

Anticonvulsant for postherpetic neuralgia and diabetic neuropathy

A

Gabapentin

39
Q

Anticonvulsant for postherpetic neuralgia and diabetic neuropathy and fibromyalgia

A

Pregablin

40
Q

Anticonvulsant for migraine prophylaxis

A

Valproate

Topiramate

41
Q

DOC glucocorticoid

A

Dexamethasone

42
Q

Misc Adjuvants

A 
Hydroxyzine
Clonidine
Lidocaine
Capsaicin
Caffeine

Pharm Midterm 2 (52 decks)

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