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Pharm Midterm 2 > Hepatic Antivirals > Flashcards

Hepatic Antivirals Flashcards

1
Q

Interferon

A

Alpha

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2
Q

Nucleotide/side inhibitors

A

Lamivudine
Adefovir
Telbivudine
Entecavir

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3
Q

What are the Protease inhibitors

A

Boceprevir

Telaprevir

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4
Q

How does IFN-alpha work

A

Inhibit RNA/DNA synth

Induces protein expression to decrease infection

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5
Q

What does IFN-alpha act on

A

HBV, HCV
Condyloma
Hairy cell leukemia
Kaposi’s

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6
Q

How do you improve the PK of IFN-alpha

A

PEGylation

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7
Q

IFN-alpha AE

A

Mental depression
Fever/chills
Fatigue

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8
Q

Toxic accumulation of Theophylline may occur

A

IFN-alpha

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9
Q

How do you activate nucleotide/side analogs

A

Phosphorylation

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10
Q

How does Lamivudine work

A 
Inhibition of HBV and HIV-RT
Chain termination (monotherapy)
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11
Q

Lamivudine AE

A

HA, dizziness

GI

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12
Q

HBV exacerbation on discontinuation

A

Adefovir

Entecavir

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13
Q

How does Adefovir work

A

Decrease HBV DNA synth

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14
Q

What does Adefovir act on

A

HBV

HIV

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15
Q

Adefovir AE

A

Nephrotoxic

Lactic acidosis

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16
Q

What inhibits viral polymerase and viral RT via competition

A

Entecavir

Telbivudine

17
Q

What does Entecavir act on

A

Lamivudine resistant HBV/HIV

18
Q

What does Telbivudine act on

A

HBV

19
Q

When do you give Protease inhibitors

A

IFN or Ribavirin failed

20
Q

What should you avoid while on Entecavir

A

Drugs with renal toxicity

21
Q

How do Protease inhibitors work

A

Bind non-structural protein 3 serine protease
Decrease replication
Reversible

22
Q

What do Protease inhibitors act on

A

HCV

23
Q

Protease Inhibitor AE

A

Fatigue, Anemia
Nausea, HA
Dysphagia

Pharm Midterm 2 (52 decks)

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