Hepatic Antivirals Flashcards
Interferon
Alpha
Nucleotide/side inhibitors
Lamivudine
Adefovir
Telbivudine
Entecavir
What are the Protease inhibitors
Boceprevir
Telaprevir
How does IFN-alpha work
Inhibit RNA/DNA synth
Induces protein expression to decrease infection
What does IFN-alpha act on
HBV, HCV
Condyloma
Hairy cell leukemia
Kaposi’s
How do you improve the PK of IFN-alpha
PEGylation
IFN-alpha AE
Mental depression
Fever/chills
Fatigue
Toxic accumulation of Theophylline may occur
IFN-alpha
How do you activate nucleotide/side analogs
Phosphorylation
How does Lamivudine work
Inhibition of HBV and HIV-RT Chain termination (monotherapy)
Lamivudine AE
HA, dizziness
GI
HBV exacerbation on discontinuation
Adefovir
Entecavir
How does Adefovir work
Decrease HBV DNA synth
What does Adefovir act on
HBV
HIV
Adefovir AE
Nephrotoxic
Lactic acidosis
What inhibits viral polymerase and viral RT via competition
Entecavir
Telbivudine
What does Entecavir act on
Lamivudine resistant HBV/HIV
What does Telbivudine act on
HBV
When do you give Protease inhibitors
IFN or Ribavirin failed
What should you avoid while on Entecavir
Drugs with renal toxicity
How do Protease inhibitors work
Bind non-structural protein 3 serine protease
Decrease replication
Reversible
What do Protease inhibitors act on
HCV
Protease Inhibitor AE
Fatigue, Anemia
Nausea, HA
Dysphagia
