GI drugs for IBD Flashcards
What are the Aminosalicylates
Sulfasalazine
Balsalazide
Mesalamine
What are the Immunomodulators
MTX
6-MP
Azathioprine
What are the Anti-TNFalpha
Infliximab
Adalimumab
What is the Anti-integrin
Natalizumab
What are the Glucocorticoids
Hydrocortisone
Prednisone
Prednisolone
Budesonide
What should you avoid in sulfa allergies
Aminosalicylates
Administration of what can cause Progressive Multifocal Leukoencephalopathy (PML)
Natalizumab
What inhibits IL-1,8, TNF-alpha
Glucocorticoids
What can reactivate latent TB
Anti-TNFalpha
What is Sulfasalazine a prodrug of
Sulfapyridine and 5-ASA
What is the drug form of 5-ASA
Mesalamine
What does 5-ASA inhibit
IL-1, TNFalpha
When do you give Aminosalicylates
Crohn’s
UC
What are the AE of Sulfapyridine
N/V/D
Hypersensitivity
BM suppression
What do immunoregulators do
Inhibit purine synth
General immune supression
What does MTX inhibit
DHF reductase
What does 6-MP do
Promote apoptosis
What do you give immunoregulators for
Crohn’s
UC
What does Azathioprine become
6-MP
What can 6-MP cause
GI mucositis
Hepatotoxicity
Myelosuppression
Why do we administer Infliximab or Adalimumab in Crohn’s
TNFalpha is the major mediator
When else can we administer Anti-TNFalpha
RA
What are the AE of Anti-TNFalpha
Fever, chills, uticaria
Hypotension
Development of Abs
Where is budesonide released
Distal ileum and colon
When do you give glucocorticoids
Acute IBD
What does Natalizumab block
Leukocyte integrins
