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Pharm Midterm 2 > GI drugs for IBD > Flashcards

GI drugs for IBD Flashcards

1
Q

What are the Aminosalicylates

A

Sulfasalazine
Balsalazide
Mesalamine

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2
Q

What are the Immunomodulators

A

MTX
6-MP
Azathioprine

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3
Q

What are the Anti-TNFalpha

A

Infliximab

Adalimumab

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4
Q

What is the Anti-integrin

A

Natalizumab

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5
Q

What are the Glucocorticoids

A

Hydrocortisone
Prednisone
Prednisolone
Budesonide

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6
Q

What should you avoid in sulfa allergies

A

Aminosalicylates

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7
Q

Administration of what can cause Progressive Multifocal Leukoencephalopathy (PML)

A

Natalizumab

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8
Q

What inhibits IL-1,8, TNF-alpha

A

Glucocorticoids

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9
Q

What can reactivate latent TB

A

Anti-TNFalpha

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10
Q

What is Sulfasalazine a prodrug of

A

Sulfapyridine and 5-ASA

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11
Q

What is the drug form of 5-ASA

A

Mesalamine

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12
Q

What does 5-ASA inhibit

A

IL-1, TNFalpha

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13
Q

When do you give Aminosalicylates

A

Crohn’s

UC

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14
Q

What are the AE of Sulfapyridine

A

N/V/D
Hypersensitivity
BM suppression

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15
Q

What do immunoregulators do

A

Inhibit purine synth

General immune supression

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16
Q

What does MTX inhibit

A

DHF reductase

17
Q

What does 6-MP do

A

Promote apoptosis

18
Q

What do you give immunoregulators for

A

Crohn’s

UC

19
Q

What does Azathioprine become

A

6-MP

20
Q

What can 6-MP cause

A

GI mucositis
Hepatotoxicity
Myelosuppression

21
Q

Why do we administer Infliximab or Adalimumab in Crohn’s

A

TNFalpha is the major mediator

22
Q

When else can we administer Anti-TNFalpha

A

RA

23
Q

What are the AE of Anti-TNFalpha

A

Fever, chills, uticaria
Hypotension
Development of Abs

24
Q

Where is budesonide released

A

Distal ileum and colon

25
Q

When do you give glucocorticoids

A

Acute IBD

26
Q

What does Natalizumab block

A

Leukocyte integrins

Pharm Midterm 2 (52 decks)

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