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Pharm Midterm 2 > Anticancer - Signal Transduction Inhibitors > Flashcards

Anticancer - Signal Transduction Inhibitors Flashcards

1
Q

What are the Signal Transduction Inhibitors

A 
Imatinib
Gefitinib
Cetuximab
Trastuzumab
Bortezomib
Sunitinib
Erlotinib
Lapatinib
Sorafenib
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2
Q

When do you give Imatinib

A

BCR-ABL+ Neoplasm

CML, AML, GIST

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3
Q

How does Imatinib work

A

Inhibit Tyrosine Kinase activity
Inhibit proliferation
Apoptosis

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4
Q

What are the Imatinib AE

A

Fluid retention/Edema
Hepatotoxicity
Thrombocytopenia

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5
Q

What does Gefitinib do

A

Inhibit EGFR signal transduction
Decrease Growth
Apoptosis

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6
Q

1st line NSCLC with EGFR mutations

A

Gefitinib

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7
Q

What are the Gefitinib AE

A

Acne-like lesions

N/D

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8
Q

What inhibits EGFR

A

Gefitinib
Cetuximab
Erlotinib
Lapatinib

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9
Q

When do you give Cetuximab

A

Colorectal
Head
Neck

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10
Q

What are the Cetuximab AE

A

Infusion rxn
Rash
Fatigue

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11
Q

What is the EGFR2 receptor mutation called

A

Her2/Neu

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12
Q

What does Trastuzimab do

A

Binds EGFR2 and mediates ADCC

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13
Q

When do you give Trastuzimab

A

Breast

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14
Q

What are the Trastuzimab AE

A

CHF

Infusion-related side-effects

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15
Q

What inhibits protease activity

A

Bortezomib

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16
Q

When do you give Bortezomib

A

Multiple Myeloma

Mantle Cell Lymphoma

17
Q

What are the Bortezomib AE

A

Thrombocytopenia

Neuropathy

18
Q

What blocks PDGF and VEGF

A

Sunitinib

Sorafenib

19
Q

When do you give Sunitinib

A

RCC

GIST

20
Q

What are the Sunitinib AE

A

Skin rash

Bleeding

21
Q

When do you give Erlotinib or Lapanitib

A

NSCLC

Pancreatic CA

22
Q

What are the AE for Erlotinib and Lapanitib

A

Skin rash

Interstitial Lung Disease

23
Q

When do you give Sorafenib

A

RCC

HCC

24
Q

What are the Sorafenib AE

A

Skin rash

Fatigue

25
Q

What can you give for RCC

A

Sunitinib

Sorafenib

26
Q

What can you give for GIST

A

Imatinib

Sunitinib

27
Q

What can cause a Skin Rash

A

Sunitinib
Sorafenib
Cetuximab

Pharm Midterm 2 (52 decks)

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