Anticancer - Signal Transduction Inhibitors Flashcards
What are the Signal Transduction Inhibitors
Imatinib Gefitinib Cetuximab Trastuzumab Bortezomib Sunitinib Erlotinib Lapatinib Sorafenib
When do you give Imatinib
BCR-ABL+ Neoplasm
CML, AML, GIST
How does Imatinib work
Inhibit Tyrosine Kinase activity
Inhibit proliferation
Apoptosis
What are the Imatinib AE
Fluid retention/Edema
Hepatotoxicity
Thrombocytopenia
What does Gefitinib do
Inhibit EGFR signal transduction
Decrease Growth
Apoptosis
1st line NSCLC with EGFR mutations
Gefitinib
What are the Gefitinib AE
Acne-like lesions
N/D
What inhibits EGFR
Gefitinib
Cetuximab
Erlotinib
Lapatinib
When do you give Cetuximab
Colorectal
Head
Neck
What are the Cetuximab AE
Infusion rxn
Rash
Fatigue
What is the EGFR2 receptor mutation called
Her2/Neu
What does Trastuzimab do
Binds EGFR2 and mediates ADCC
When do you give Trastuzimab
Breast
What are the Trastuzimab AE
CHF
Infusion-related side-effects
What inhibits protease activity
Bortezomib
When do you give Bortezomib
Multiple Myeloma
Mantle Cell Lymphoma
What are the Bortezomib AE
Thrombocytopenia
Neuropathy
What blocks PDGF and VEGF
Sunitinib
Sorafenib
When do you give Sunitinib
RCC
GIST
What are the Sunitinib AE
Skin rash
Bleeding
When do you give Erlotinib or Lapanitib
NSCLC
Pancreatic CA
What are the AE for Erlotinib and Lapanitib
Skin rash
Interstitial Lung Disease
When do you give Sorafenib
RCC
HCC
What are the Sorafenib AE
Skin rash
Fatigue
What can you give for RCC
Sunitinib
Sorafenib
What can you give for GIST
Imatinib
Sunitinib
What can cause a Skin Rash
Sunitinib
Sorafenib
Cetuximab
