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Pharm Midterm 2 > Anticancer - Antimetabolites > Flashcards

Anticancer - Antimetabolites Flashcards

1
Q

What is the Folate antagonist

A

MTX

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2
Q

What are the Purine Antagonists

A

6-MP

6-thioguanine

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3
Q

What are the Pyrimadine antagonists

A

5-FU
Capecitabine
Gemcitabine
Cytarabine

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4
Q

What can you give with MTX to minimize side effects

A

Leucovorin

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5
Q

What does MTX do

A

Inhibit DHF reductase

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6
Q

What are the main MTX AE

A

Renal damage (crystals in tubules)

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7
Q

What happens when you add Leucorvin to 5-FU

A

Increases 5-FU cytotoxicity

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8
Q

What is the main Gemcitabine AE

A

Elevated liver enzymes (AST/ALT)

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9
Q

What is the main Cytarabine AE

A

Ataxia

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10
Q

What is the main use for Gemcitabine

A

Pancreatic Cancer

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11
Q

How do we administer MTX in cancer

A

Short term, High dose

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12
Q

How do we administer MTX in RA

A

Long term, Low dose

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13
Q

What does MTX inhibit in RA

A

AICAR transformylase

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14
Q

When do we give MTX

A 
Choriocarcinoma
ALL
Burkitt's
Osteosarcoma
Breast CA
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15
Q

What are the other MTX AE

A 
BM/Immuno suppression
Mucositis
Alopecia
Pulm tox (Children)
Heptatic fibrosis (long term)
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16
Q

What metabolizes 6-MP

A

Xanthine Oxidase

17
Q

What is 6-MP given for

18
Q

How does 6-MP work

A

Converted to TIMP inhibiting de novo purine synth

Block formation of AMP & GMP

19
Q

What are the 6-MP AE

A

BM suppression
Hepatotoxicity
N/V

20
Q

What is useful about 6-thioguanine over 6-MP

A

No interaction with Allopurinol

21
Q

How does 6-thioguanine work

A

Decrease GMP

Inhibit DNA/RNA synth

22
Q

What is 6-thioguanine used for

23
Q

What are the 6-thioguanine AE

A

BM suppression
Hepatotoxicity
N/V

24
Q

How do 5-FU and Capecitabine work

A

Inhibit Thymidylate Synthase

Incorporation into RNA

25
Q

What are 5-FU and Capecitabine given for

A

Systemic adenocarcinoma
Metastatic Breast CA
Colorectal CA
Topical for skin cancer

26
Q

What are the 5-FU and Capecitabine AE

A

Hand/Foot syndrome
Myelosuppression
Mucositis
Alopecia

27
Q

What is Hand/Foot syndrome

A

Skin exfoliation causing erythematous desquamation

28
Q

How does Gemcitabine work

A

Incorporated into DNA

Inhibits DNAP

29
Q

What else can Gemcitabine work on

A

NSCLC

Ovarian CA

30
Q

What are the other Gemcitabine AE

A

Myelosuppression
Alopecia
Flu-like Sx

31
Q

What is the active form of Cytarabine

32
Q

How does Cytarabine work

A

S-phase

Inhibit DNAP

33
Q

What is Cytarabine used for

A

Induction therapy in AML

Blast crisis in CML

34
Q

What is the other Cytarabine AE

A

Myelosuppression

Pharm Midterm 2 (52 decks)

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