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Pharm Midterm 2 > Antiamebics > Flashcards

Antiamebics Flashcards

1
Q

What are the mixed luminal and systemic agents

A

Metro

Tinidazole

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2
Q

What are the Luminal agents

A

Diloxanide Furoate
Iodoquinol
Paromomycin

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3
Q

What are the Systemic agents

A

Chloroquine
Dehydroemetine
Emetine

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4
Q

How does Metronidazole work

A

Non-enzymatic reduction with ferredoxin

Cytotoxic compounds bind protein and DNA

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5
Q

What is a 2nd gen nitroimidazole

A

Tinidazole

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6
Q

DOC invasive amebiasis with luminal agent

A

Metro

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7
Q

What is the alternative Tx for Invasive Amebiasis

A

Tetracycline

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8
Q

What does Metro act on

A 
G. Lamlia
T. vaginalis
H. pylori
C. difff
Anaerobic cocci
G- bacilli
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9
Q

Which Antiamebic is metabolized by P450

A

Metro

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10
Q

Main Metro AE

A

Disulfiram-like reaction

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11
Q

What are the general Metro AE

A 
Dark urine
GI distress
Metallic taste
Oral moniliasis
Leukopenia, dizziness
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12
Q

What is Tinidazole for

A

Amebiasis (no shit sherlock)
Amebic liver abscess
Giardiasis
Trichomoniasis

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13
Q

Why would you give Tinidazole over Metro

A

Better tolerated (shorter AE)

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14
Q

Which Antiamebic is converted to an active form in the gut

A

Diloxanide Furoate

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15
Q

DOC Asymptomatic Amebiasis

A

Diloxanide Furoate

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16
Q

What can you give Diloxanide Furoate with for moderate/severe infections

A

Metro

17
Q

Diloxanide Furoate AE

A

GI distress

18
Q

What is Iodoquinol used for

A

Luminal trophozoite

Cyst forms of E. histolytica

19
Q

What is the main Iodoquinol AE

A

Peripheral neuropathy

20
Q

What are the general Iodoquinol AE

A

Rash

Diarrhea

21
Q

Which Antiamebic is an aminoglycoside ABX

A

Paromomycin

22
Q

How does Paromomycin work

A

Bind 30S

23
Q

What is Paromomycin used for

A

Luminal E. histolytica and tapeworm

Alternative for AIDS crypto

24
Q

What are the Paromomycin AE

A 
Diarrhea
HA
Dizziness
Rash
Arthralgia
25
Q

What does Chloroquine do

A

Eliminate trophozoites in liver abscess

26
Q

What do you give with Chloroquine

A

Metro

Diloxanide Furoate

27
Q

What blocks ribosomal movement along RNA

A

Dihydroemetine

Emetine

28
Q

What are Dehydroemetine and Emetine used for

A

Backup in severe intestinal/hepatic abscess

29
Q

What do you give with Dehydroemetine and Emetine

A

Luminal agent

30
Q

Which Antiamebics concentrate in the liver

A

Dehydroemetine

Emetine

31
Q

What are the AE for Dehydroemetine and Emetine

A

Nausea, Dizziness, Rash
Cardiotox
Neuromuscular weakness

Pharm Midterm 2 (52 decks)

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