Misc. Inhibitors of Cell Wall Synthesis Flashcards
What are the misc inhibitors of cell wall synthesis
Vancomycin
Daptomycin
Bacitracin
Fosfomycin
What is beneficial about Vancomycin
Not nephrotoxic, ototoxic or causes thrombophlebitis
How does Vancomycin act
Binds D-Ala-D-Ala on nascent peptidoglycan
Increase susceptibility to lysis
What do you give with Vancomycin for enterococcal endocarditis or PRSP
Aminoglycoside
What is Vanco good for
Multi-drug resistant stuff
PCN allergy
MRSA…no shit
When is Vanco given orally
Pseudomonas enterocolitis
How is Vanco excreted
Kidney
Can Vanco penetrate CSF
If inflamed
Most notable Vanco AE
Red Man Syndrome
Flushing of face/upper torso
Most important Vanco AE in accumulation or with Aminoglycosides
Ototoxicity
Nephrotoxicity
How is Vanco resistance conferred
Modification of binding site
Changes in permeability
What is Daptomycin good for
G+
Complicated Staph
MRSA, VRE
C. Diff
How does Daptomycin work
Ca dependent insertion of lipid tail into membrane
Depolarization
K efflux causes death
Can accumulate in renal insufficiency
Daptomycin
Main Daptomycin AE
Myopathy –> Elevated CK
Stop statins
