Anticancer - General Info Flashcards
What is the Log-kill hypothesis
Fixed fraction of tumor cells killed during chemo
What kind of drugs work on cells in G0
Cell cycle non-specific drugs
How do you maximize tumor killing
Use drugs with different MOA and known efficacies
How do you minimize lethal damage
Drugs with different side effects
What cells are most commonly affected by chemo
Rapidly dividing
How do prevent resistance
Drugs affecting different parts of cell cycle
Drugs with different MOAs
What mutation confers MTX resistance
DHF reductase
What is MDR mediated by
P-glycoprotein
Where does Bleomycin act
G2
What is the Bleomycin toxicity
Pulmonary Fibrosis
Where does Vincristine act
M
What is the Vincristine toxicity
Neurotoxic
Where do Doxorubicin and Dacarbazine act
G0
What is the Doxorubicin toxicity
Cardiotoxic
What is the Dacarbazine toxicity
BM toxicity
What is the BEP regimen for Testicular Cancer
Bleomycin
Etoposide
Platinum compounds (Cisplatin)
Where does Etoposide act
Late S
Early G2
What is the Etoposide toxicity
BM toxicity
Where does Cisplatin act
G0
What are the Cisplatin toxicities
Nephrotoxicity
Ototoxixity
Adjuvant therapy
Chemo along with surgery or radiation
Neo-adjuvant therapy
Chemo before surgery
Induction chemo
Chemo for complete remission (blood cancers)
Maintenance chemo
Chemo to maintain remission