Anticancer - General Info Flashcards by Anar Itrabarkahc | Brainscape

Q

What is the Log-kill hypothesis

A

Fixed fraction of tumor cells killed during chemo

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Q

What kind of drugs work on cells in G0

A

Cell cycle non-specific drugs

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Q

How do you maximize tumor killing

A

Use drugs with different MOA and known efficacies

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Q

How do you minimize lethal damage

A

Drugs with different side effects

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Q

What cells are most commonly affected by chemo

A

Rapidly dividing

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Q

How do prevent resistance

A

Drugs affecting different parts of cell cycle

Drugs with different MOAs

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Q

What mutation confers MTX resistance

A

DHF reductase

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Q

What is MDR mediated by

A

P-glycoprotein

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Q

Where does Bleomycin act

A

G2

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Q

What is the Bleomycin toxicity

A

Pulmonary Fibrosis

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Q

Where does Vincristine act

A

M

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Q

What is the Vincristine toxicity

A

Neurotoxic

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Q

Where do Doxorubicin and Dacarbazine act

A

G0

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Q

What is the Doxorubicin toxicity

A

Cardiotoxic

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Q

What is the Dacarbazine toxicity

A

BM toxicity

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Q

What is the BEP regimen for Testicular Cancer

A

Bleomycin
Etoposide
Platinum compounds (Cisplatin)

Q

Where does Etoposide act

A

Late S

Early G2

Q

What is the Etoposide toxicity

A

BM toxicity

Q

Where does Cisplatin act

A

G0

Q

What are the Cisplatin toxicities

A

Nephrotoxicity

Ototoxixity

Q

Adjuvant therapy

A

Chemo along with surgery or radiation

Q

Neo-adjuvant therapy

A

Chemo before surgery

Q

Induction chemo

A

Chemo for complete remission (blood cancers)

Q

Maintenance chemo

A

Chemo to maintain remission