Anticancer - Natural Products Flashcards
1
Q
What are the Vinca Alkaloids
A
Vincristine
Vinblastine
Vinorelbine
2
Q
What are the Taxanes
A
Paclitaxel
Docetaxel
3
Q
What are the Epipodophyllotoxins
A
Etoposide
Teniposide
4
Q
What are the Camptothecins
A
Tropotecan
Irinotecan
5
Q
How do the Vinca Alkaloids work
A
Bind tubulin
Prevent MT formation (no spindle)
Arrest in M
6
Q
What is Vincristine given for
A
Hodgkin’s
7
Q
What is Vinblastine given for
A
Testicular CA
8
Q
What is Vinorelbine given for
A
NSCLC
9
Q
Vincristine AE
A
Neuropathy (BM sparing)
10
Q
Vinblastine AE
A
Myelosuppression
11
Q
Vinorelbine AE
A
Granulocytopenia
12
Q
How do the Taxanes work
A
Enhance and Stabilize MT formation
Arrest in M
13
Q
What are the Taxanes given for
A
Ovarian and Breast CA
14
Q
Paclitaxel AE
A
Severe allergy
Neutropenia
Alopecia
15
Q
Docetaxel AE
A
Skin toxicity
Fluid retention
