Anticancer - Natural Products Flashcards by Anar Itrabarkahc

Q

What are the Vinca Alkaloids

A

Vincristine
Vinblastine
Vinorelbine

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Q

What are the Taxanes

A

Paclitaxel

Docetaxel

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Q

What are the Epipodophyllotoxins

A

Etoposide

Teniposide

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Q

What are the Camptothecins

A

Tropotecan

Irinotecan

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Q

How do the Vinca Alkaloids work

A

Bind tubulin
Prevent MT formation (no spindle)
Arrest in M

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Q

What is Vincristine given for

A

Hodgkin’s

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Q

What is Vinblastine given for

A

Testicular CA

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Q

What is Vinorelbine given for

A

NSCLC

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Q

Vincristine AE

A

Neuropathy (BM sparing)

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Q

Vinblastine AE

A

Myelosuppression

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Q

Vinorelbine AE

A

Granulocytopenia

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Q

How do the Taxanes work

A

Enhance and Stabilize MT formation

Arrest in M

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Q

What are the Taxanes given for

A

Ovarian and Breast CA

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Q

Paclitaxel AE

A

Severe allergy
Neutropenia
Alopecia

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Q

Docetaxel AE

A

Skin toxicity

Fluid retention

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Q

When do the Epipodophyllotoxins act

A

Late S, Early G2

Q

How do Epipodophyllotoxins work

A

Topo II inhibitor

Prevent re-ligation

Q

What are the Epipodophyllotoxins for

A

Germ cell tumor
AML
Lung CA

Q

What are the Epipodophyllotoxins AE

A

Myelosuppression

Leukemia

Q

When is Irinotecan toxicity seen

A

Gilbert’s Syndrome

Q

How do the Camptothecins work

A

Topo I inhibition

Q

What is Topotecan used for

A

Ovarian CA mets

Q

What is Irinotecan used for

A

Colorectal CA

Q

Topotecan AE

A

Pancytopenia

Q

Irinotecan AE

A

Diarrhea

Myelosuppression