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Pharm Midterm 2 > Anticancer - Antitumor ABX > Flashcards

Anticancer - Antitumor ABX Flashcards

1
Q

What are the Antitumor ABX

A

Bleomycin
Doxorubicin
Daunorubicin
Dactinomycin

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2
Q

What are the Anthracyclines

A

Doxorubicin

Daunorubicin

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3
Q

Where does Bleomycin act

A

G2

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4
Q

What inactivates Bleomycin

A

Bleomycin hydrolase

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5
Q

Where is Bleomycin eliminated

A

Kidney

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6
Q

Which drugs spare BM

A

Bleomycin

Vincristine

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7
Q

How does Bleomycin work

A

Reduce Fe to generate ROS

Free radical induced strand breakage

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8
Q

What is Bleomycin given for

A

Hodgkin’s Lymphoma
Testicular CA
Kaposi’s Sarcoma

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9
Q

Bleomycin AE (low hydrolase activity)

A

Pneumonitis, Pulm fibrosis
Skin rxns, Raynaud’s
Retroperitoneal fibrosis

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10
Q

How do Anthracyclines work

A

Inhibit Topo II
Form ROS
Alter membrane fluidity

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11
Q

What are Anthracyclines given for

A

Broad spectrum cancer

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12
Q

What are the main Anthracycline AE

A

Cardiotoxicity

Erythema at site of previous radiation

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13
Q

How do you reduce Cardiotox with Anthracyclines

A

Dexrazoxane

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14
Q

How does Dexrazoxane work

A

Fe chelator

Reduces ROS

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15
Q

What are the other Anthracycline AE

A

Myelosuppression
N/V, alopecia, mucositis
Blisters

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16
Q

How does Dactinomycin work

A

Covalently binds DNA

17
Q

What is Dactinomycin given for

A

Wilms tumor

Sarcoma

18
Q

What are the Dactinomycin AE

A

Blisters

Erythema at site of previous radiation

19
Q

What is a possible blister sequelae in Dactinomycin

A

Extravasation and tissue necrosis

20
Q

What causes recall reaction (Erythema at site of previous radiation)

A

Doxorubicin
Daunorubicin
Dactinomycin

Pharm Midterm 2 (52 decks)

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