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Pharm Midterm 2 > Cephalosporins > Flashcards

Cephalosporins Flashcards

1
Q

Cephalosporin action

A

Bind PBPs

Activate Autolysin

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2
Q

What are Cephalosporins inactive against

A

Listeria, Legionella
Atypical (Chlamydia, Mycoplasma), Acinetobacter
MRSA
Enterococci

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3
Q

Oral Cephalosporins

A

Cephalexin
Cefaclor
Cefixime

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4
Q

Effect of cephalosporin combination with aminoglycosides

A

Increase aminoglycoside nephrotoxicity

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5
Q

Which cephalosporins can cause hypoprothrombinemia and disulfiram-like reaction

A

Cefamandole
Cefoperazone
Cefotetan

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6
Q

What happens when you go from 1st-3rd gen

A

Decrease G+ activity

Increase G- activity

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7
Q

Efficacy of 4th gen

A

G+ and G-

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8
Q

1st gen

A

Cefazolin

Cephalexin

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9
Q

What do you give 1st gen for

A

Proteus
E. coli
Klebsiella

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10
Q

What are 1st gen resistant to

A

Staph penicillinase

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11
Q

DOC G+ surgical prophylaxis

A

Cephazolin

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12
Q

2nd gen

A

Cefaclor
Cefoxitin
Cefotetan
Cefamandole

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13
Q

What are 2nd gen for

A 
H. influenza
Enterobacter
Nisseria
Proteus
E. coli
Klebsiella
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14
Q

Use of 2nd gen

A

When PCN can’t be used

Sinusitis, otitis, lower RTI

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15
Q

Prophylaxis/Tx for G- abd/pelvic infections

A

Cefotetan

Cefoxitin

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16
Q

3rd gen

A 
Ceftriaxone
Cefoperazone
Cefotaxime
Ceftazidime
Cefixime
17
Q

What are 3rd gen used for

A

H. Influenza
Enterobacteriaceae
Nisseria

18
Q

Pneumococcal infections

A

Cefotaxime

Ceftriaxone

19
Q

Ceftriaxone is DOC for

A

N. gonorrhea
Meningitis (amp res H. influenzae)
Lyme disease w/ CNS and joint

20
Q

Meningitis prophylaxis

A

Ceftriaxone
Ciprofloxacin
Rifampin

21
Q

Lyme disease w/o CNS and joint

A

Doxycycline

22
Q

P. aeruginosa

A

Cefoperazone

Ceftazidime

23
Q

4th gen

A

Cefepime

24
Q

Cefapime administration

A

IV

25
Q

Empiric for serious infection

A

Cefepime

26
Q

What can you give Cefepime for

A 
Haemophillus
Neisseria
E. coli
Pneumococci
P. mirabilis
P. aeruginosa

Pharm Midterm 2 (52 decks)

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