Cephalosporins Flashcards
Cephalosporin action
Bind PBPs
Activate Autolysin
What are Cephalosporins inactive against
Listeria, Legionella
Atypical (Chlamydia, Mycoplasma), Acinetobacter
MRSA
Enterococci
Oral Cephalosporins
Cephalexin
Cefaclor
Cefixime
Effect of cephalosporin combination with aminoglycosides
Increase aminoglycoside nephrotoxicity
Which cephalosporins can cause hypoprothrombinemia and disulfiram-like reaction
Cefamandole
Cefoperazone
Cefotetan
What happens when you go from 1st-3rd gen
Decrease G+ activity
Increase G- activity
Efficacy of 4th gen
G+ and G-
1st gen
Cefazolin
Cephalexin
What do you give 1st gen for
Proteus
E. coli
Klebsiella
What are 1st gen resistant to
Staph penicillinase
DOC G+ surgical prophylaxis
Cephazolin
2nd gen
Cefaclor
Cefoxitin
Cefotetan
Cefamandole
What are 2nd gen for
H. influenza Enterobacter Nisseria Proteus E. coli Klebsiella
Use of 2nd gen
When PCN can’t be used
Sinusitis, otitis, lower RTI
Prophylaxis/Tx for G- abd/pelvic infections
Cefotetan
Cefoxitin
3rd gen
Ceftriaxone Cefoperazone Cefotaxime Ceftazidime Cefixime
What are 3rd gen used for
H. Influenza
Enterobacteriaceae
Nisseria
Pneumococcal infections
Cefotaxime
Ceftriaxone
Ceftriaxone is DOC for
N. gonorrhea
Meningitis (amp res H. influenzae)
Lyme disease w/ CNS and joint
Meningitis prophylaxis
Ceftriaxone
Ciprofloxacin
Rifampin
Lyme disease w/o CNS and joint
Doxycycline
P. aeruginosa
Cefoperazone
Ceftazidime
4th gen
Cefepime
Cefapime administration
IV
Empiric for serious infection
Cefepime
What can you give Cefepime for
Haemophillus Neisseria E. coli Pneumococci P. mirabilis P. aeruginosa
