Resp Antivirals Flashcards by Anar Itrabarkahc | Brainscape

Q

Neuraminidase Inhibitors

A

Oseltamivir

Zanamivir

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Q

Ion Channel Blockers

A

Amatadine

Rimantadine

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Q

Nucleotide/side Analog

A

Ribavirin

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Q

When do Neuraminidase inhibitors work best

A

Prophylaxis

Within 24hrs of exposure kinda ok

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Q

How do Neuraminidase inhibitors work

A

Inhibit viral release (inhibit sialic acid substrate)

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Q

What are Neuraminidase inhibitors used for

A

Influenza A, B

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Q

Which Neuraminidase Inhibitor is a prodrug

A

Oseltamivir

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Q

Neuraminidase Inhibitor is inhaled

A

Zanamivir

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Q

Oseltamivir AE

A

GI discomfort

Nausea

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Q

Zanamivir AE

A

Airway irritation

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Q

How do Ion Channel Blockers work

A

Block M2

Needed for fusion

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Q

What do Ion Channel Blockers work on

A

Influenza A

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Q

Why are Ion Channel Blockers not recommended

A

50% pts naturally resistant

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Q

Ion Channel Blockers Pregnancy

A

Category C

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Q

Which Ion Channel Blocker can cross BBB

A

Amatadine

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Q

Ion Channel Blocker AE

A

GI effects

Q

Amatadine AE

A

GI, CNS

Q

What can Amatadine do in psych pts

A

Epilepsy
Renal impairment
So monitor that shit

Q

What is Ribavirin

A

Guanosine analog

Works for DNA and RNA viruses

Q

How does Ribavirin act

A

Inhibit GTP formation
Prevents mRNA capping
Inhibits RDRP

Q

What do you give Ribavirin for

A

RSV
HCV
Lassa fever

Q

Can you give Ribavirin in Pregnancy

A

Fuck NO

Category X

Q

Ribavirin AE

A

Hemolytic anemia
Nausea, anorexia
CNS

Q

Where does Ribavirin persist

A

RBCs

Q

How is Ribavirin administered

A

Oral
IV
Aerosol

Q

How are Ion Channel Blockers administered

A

Oral