Resp Antivirals Flashcards
Neuraminidase Inhibitors
Oseltamivir
Zanamivir
Ion Channel Blockers
Amatadine
Rimantadine
Nucleotide/side Analog
Ribavirin
When do Neuraminidase inhibitors work best
Prophylaxis
Within 24hrs of exposure kinda ok
How do Neuraminidase inhibitors work
Inhibit viral release (inhibit sialic acid substrate)
What are Neuraminidase inhibitors used for
Influenza A, B
Which Neuraminidase Inhibitor is a prodrug
Oseltamivir
Neuraminidase Inhibitor is inhaled
Zanamivir
Oseltamivir AE
GI discomfort
Nausea
Zanamivir AE
Airway irritation
How do Ion Channel Blockers work
Block M2
Needed for fusion
What do Ion Channel Blockers work on
Influenza A
Why are Ion Channel Blockers not recommended
50% pts naturally resistant
Ion Channel Blockers Pregnancy
Category C
Which Ion Channel Blocker can cross BBB
Amatadine
Ion Channel Blocker AE
GI effects
Amatadine AE
GI, CNS
What can Amatadine do in psych pts
Epilepsy
Renal impairment
So monitor that shit
What is Ribavirin
Guanosine analog
Works for DNA and RNA viruses
How does Ribavirin act
Inhibit GTP formation
Prevents mRNA capping
Inhibits RDRP
What do you give Ribavirin for
RSV
HCV
Lassa fever
Can you give Ribavirin in Pregnancy
Fuck NO
Category X
Ribavirin AE
Hemolytic anemia
Nausea, anorexia
CNS
Where does Ribavirin persist
RBCs
How is Ribavirin administered
Oral
IV
Aerosol
How are Ion Channel Blockers administered
Oral
