GI drugs - Laxatives Flashcards by Anar Itrabarkahc

Q

What are the bulk forming drugs

A

Methylcellulose
Psyllium
Bran

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Q

What are the stool softeners

A

Docusate
Mineral Oil
Glycerine

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Q

What are the osmotic agents

A

Mg salts
Mg(OH)3
Lactulose
Polyethylene Glycol

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Q

What are the GI stimulants

A

Senna
Bisacodyl
Castor Oil

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Q

What is the Cl channel activator

A

Lubiprostone

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Q

What are the Opioid antagonists

A

Alvimopan

Methylnaltrexone

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Q

What distends the bowels to stimulate peristalsis

A

Bulk forming drugs

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Q

What do you give got hepatic encephalopathy

A

Lactulose

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Q

What is the Tx for opioid constipation

A

Senna and Docusate

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Q

How does Lactulose treat hepatic encephalopathy

A

Draws out NH3 to prevent hyperammonemia

Acidification of gut lumen traps NH4+

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Q

Where do bulk forming drugs come from

A

Fruits and Vegetables

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Q

What does taking bulk forming drugs require

A

High fluid intake

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Q

When do you not give bulk forming drugs

A

Opioid constipation

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Q

What do you combine stool softeners with for opioid constipation

A

GI Stimulant

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Q

How Osmotic Agents act

A

Draw water into lumen to stimulate motility

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Q

What are osmotic agents used for

A

Constipation

Prep for endoscopy (PEG)

Q

How does Lubiprostone work

A

Increase fluid content by stimulating Cl secretion

Q

When do you give Lubiprostone

A

Constipation

IBS

Q

How do opioid antagonists work

A

Block GI mu receptors without entering CNS

Q

What do opioid antagonists do

A

Increase Ach and peristalsis