Additional Antiretrovirals Flashcards by Anar Itrabarkahc | Brainscape

Q

What are the additional retrovirals

A

Enfuvirtide
Raltegravir
Maraviroc

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Q

What does Enfuvirtide do

A

Fusion inhibitor

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Q

What does Raltegravir do

A

Integrase strand transfer inhibitor (INSTI)

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Q

How does Enfuvirtide work

A

Similar structure to gp41

Binds gp41 and prevents virion fusion

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Q

Does Enfuvirtide interact with other anti-retrovirals

A

No

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Q

What does Maraviroc do

A

Entry inhibitor

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Q

How does Raltegravir work

A

Binds Integrase on HIV 1,2

Inhibits viral genome integration into host DNA

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Q

What metabolizes Raltegravir

A

UGT1A1 glucuronidation

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Q

What decreases the serum conc of Raltegravir

A

Rifampin
Tipranavir
Efavirenz

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Q

What increases the serum conc of Raltegravir

A

PPIs

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Q

Raltegravir AE

A

Increase creatine phosphokinase
N/D
HA

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Q

How does Maraviroc work

A

Bind CCR5 blocking entry into cell

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Q

What metabolizes Maraviroc

A

3A4

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Q

Maraviroc AE

A

Hepatotoxicity

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