PHAR232 - receptors and targets Flashcards
What are receptor tyrosine kinases (RTKs)?
A kinase putting a phosphate on tyrosine
What’s another name for receptor tyrosine kinases (RTKs)?
Kinase linked receptors
How many estimated genes have been associated with RTKs?
59 genes
Quick review
What does a kinase do?
Puts a phosphate on
(phosphorylation = activation)
What does a phosphatase do?
Takes phosphates off
(dephosphorylation = deactivation)
What is dimerisation?
two molecules come together to form a dimer, a complex consisting of two subunits.
What is growth factor receptor signalling especially goal orientated towards?
Gene transcription
What is the primary goal of the nuclear receptors?
Alter gene transcription
- bind directly to DNA to trigger transcription of designated genes
What is another name for DNA binding domain?
Zinc fingers
Activation of gene tranription occurs in what 2 phases?
- Primary response (within 30 mins)
- Secondary response (utilises primary genes and takes longer)
What are 2 non ligand-gated ion channels?
- Voltage-gated
- Small cation channels