NEUR 531 - Corpus Striatum Flashcards
1
Q
Basal ganglia 3 subsets
A
– corpus striatum
– Subthalamic nucleus
– Substantia nigra
2
Q
What are the basal ganglia associated with:
A
- Initiation of movement
- sequencing of movements
- set up the correct motor programs to
execute complex simultaneous and sequential movements
3
Q
another term for Caudate of the putamen
A
Striatum
4
Q
What are 3 striatal afferents?
A
Cortex, thalamus, substantia nigra
5
Q
Corticostriate fibres are all what?
A
- Excitatory - Glu
- PFC
- Parietal
6
Q
Topographically organised
A
- Somatosensory and motor - putamen
- Libic (parahippocampal and cingulate) nucleus accumbens
- Association cortical areas - caudate nucleus
7
Q
Nigrostriate fibres are associated with what?
A
- Substantia nigra pars compacta - putamen
- Ventral tegmental area - nucleus accumbens
- Dopamine E & I
8
Q
Striatopallidal fibres are all what…
A
- Inhibitory - GABA
9
Q
Strial efferents
A
- Globus pallidus
- Substantia nigra
10
Q
Striatonigral fibres
A
- All inhibitory
- Substantia nigra pars compacta - shut off dopamine
- Substantia nigra pars reticulata - GABAergic
11
Q
Afferent and efferent connections of the striatum
A
12
Q
Pallidal efferents -
A
- Thalamus
- Pedunculopontine nucleus
- Habenula
- Superior colliculus
- All injibitory GABA)
13
Q
Pallidothalamic fibres
A
-Internal globus pallidus
- External globus pallidus
14
Q
Caudate nucleus
A
15
Q
Lentiform nucleus
A
17
Q
A
18
Q
A
19
Q
study for exam
A
20
Q
STUDY FOR EXAM
A
-
21
Q
Dopaminergic inputs
A
- Can be E or I
22
Q
What is the role of doapmine
A
- Direct pathway - Excitatory D1 receptor bound
- Indirect pathways - Inhibitory D2 receptors
23
Q
Inhibitory dopamine pathway
A
24
Q
A
- Red is tonically active pathway (GABAergic)
- Baseline
25
Q
Parallel circuits of the corpus striatum
A
