NEUR 531 - Corpus Striatum Flashcards
Basal ganglia 3 subsets
– corpus striatum
– Subthalamic nucleus
– Substantia nigra
What are the basal ganglia associated with:
- Initiation of movement
- sequencing of movements
- set up the correct motor programs to
execute complex simultaneous and sequential movements
another term for Caudate of the putamen
Striatum
What are 3 striatal afferents?
Cortex, thalamus, substantia nigra
Corticostriate fibres are all what?
- Excitatory - Glu
- PFC
- Parietal
Topographically organised
- Somatosensory and motor - putamen
- Libic (parahippocampal and cingulate) nucleus accumbens
- Association cortical areas - caudate nucleus
Nigrostriate fibres are associated with what?
- Substantia nigra pars compacta - putamen
- Ventral tegmental area - nucleus accumbens
- Dopamine E & I
Striatopallidal fibres are all what…
- Inhibitory - GABA
Strial efferents
- Globus pallidus
- Substantia nigra
Striatonigral fibres
- All inhibitory
- Substantia nigra pars compacta - shut off dopamine
- Substantia nigra pars reticulata - GABAergic
Afferent and efferent connections of the striatum
Pallidal efferents -
- Thalamus
- Pedunculopontine nucleus
- Habenula
- Superior colliculus
- All injibitory GABA)
Pallidothalamic fibres
-Internal globus pallidus
- External globus pallidus
Caudate nucleus
Lentiform nucleus
Internal globus pallidus - direct input into the thalamus
*Ventral lateral nucleus – premotor cortex
* Ventral anterior nucleus – premotor (frontal eye field)
* Mediodorsal nucleus – prefrontal and cingulate (limbic)
study for exam
STUDY FOR EXAM
-
Dopaminergic inputs
- Can be E or I
What is the role of doapmine
- Direct pathway - Excitatory D1 receptor bound
- Indirect pathways - Inhibitory D2 receptors
Inhibitory dopamine pathway
- Red is tonically active pathway (GABAergic)
- Baseline
Parallel circuits of the corpus striatum
