P9 - Inflammation Part 4 Flashcards
exudate is part of
- active part of inflammation
exudate components (3)
- fluid component
- cellular component
- chemical component
fluid component of exudate
- medium for cells, nutrients and other factors
cellular component of exudate
- granulocytes and mononuclear cells
chemical component of exudate
- factors that drive and regulate inflammation
transudate is part of
- passive congestion
transudate and exudate effect on vascular permeability
- exudate -> increased
- transudate -> no change
transudate and exudate protein content
- transudate - low
- exudate - 2.5-3
transudate and exudate cells
- transudate - rare cells present
- exudate - high number of inflammatory cells
exudate categorized based on timeframe
- acute ( <10 days)
- chronic ( >10 days)
types of acute exudate (5)
- serous
- serohemorrhagic
- fibrinous
- catarrhal
- purulent
types of chronic exudate (2)
- granulomatous
- lymphoplasmacytic
exudate that is composed of blood plasma with very few cells
- often seen in cavities, skin, lungs and mucosal surfaces
- high in protein
- changes in vascular permeability
- very few inflammatory cells
serous
exudate that is a result of vascular damage or widespread diapedesis that red tinged
serohemorrhagic
benefit of serous and serohemorrhagic exudate (2)
- dilute bacteria
- increase nutrients that tissue needs
cost of serous and serohemorrhagic exudate
- problematic when fills cavities on in respiratory tract
fibrinogen escapes vasculature and is converted to
- fibrin
pseudomembrane associate with fibrinous exudate
- mat of fibrin that can be pulled off
- epithelium stay in tact
diphtheritic membrane associated with fibrinous exudate
- pulling off mat results in ulceration
- epithelium is pulled off
fibrin cast associated with fibrinous exudate
- fibrin discharged from organ as single hard structure
benefit of fibrinous exudate
- layer of protection
- pathogen entrapment
cost of fibrinous exudate
- impede absorption
- can form adhesions restricting function and movement of organs
prolonged fibrinous exudate becomes framework for
fibrous connective tissue
- cannot be pulled off
exudate that is mucous cell hyperplasia
catarrhal
benefit of catarrhal exudate
- immunity (entraps bacteria and pathogens)
- protect mucosal surface from damage
- contains inflammatory factors and flushes foreign material
cost of catarrhal exudate
- can be hard to clear
neutrophilic exudate
purulent
empyema
- pus filled body cavities
type of necrosis associated with purulent exudate
- liquefactive
benefit of purulent exudate
- highly effective
- non-specific method of neutralizing many etiologies
costs of purulent exudate
- can cause passive destruction of host tissue
exudate that is predominately epitheloid macrophages with fewer lympocytes and plasma cells
- granulomatous
gross appearance of granulomatous exudate
- enlarged
- firm
- pale
granuloma
- type of granulomatous inflammation
- distinct aggregates of macrophages that wall off inciting cause
benefit of granulomatous exudate
- robust mechanism to eliminate or sequester inciting cause
cost of granulomatous exudate
- body is beginning to concede that containment may be best option
exudate with mix of lymphocytes and plasma cells often in typical areas
- lymphoplasmactic
benefit of lymphoplasmactic exudate
- inclusion of adaptive immunity in inflammatory response
cost of lymphoplasmactic exudate
- extensive inflammatory infiltrates likely contribute to organ dysfunction
mixed inflammatory infiltrates
- dynamic and continuous
- more than 1 inflammatory process may be occurring
