P43 - Integumentary Part 5

Question 1

important veterinary poxvirus disease

Answer 1

• sheepox and goatpox

- lumpy skin disease

Question 2

poxviruses pathogenesis

Answer 2

• viral invasion of epithelium -> stimulation of host DNA causes epidermal and dermal hyperplasia -> vascular injury and ischemic necrosis -> proliferative and necrotizing

Question 3

poxviruses lesion development

Answer 3

• macule -> papule -> vesicle -> umbilicated pustule -> crust -> scar

Question 4

dermatotropic herpesviruses

Answer 4

• bovine herpesvirus 2 and 4

Question 5

pathogenesis of herpesviruses

Answer 5

• viral infection of epithelial cells with replication in nucleus -> lysis of nuclear contents and degeneration of organelles -> cell death with spread leads to multifocal tissue necrosis

Question 6

herpesvirus lesion development

Answer 6

• vesicle -> ulcer -> crusts

Question 7

papillomaviruses pathogenesis

Answer 7

• viral infection of squamous epithelium -> integration into host cell genome -> inactivation of tumor suppressor genes (p53 and Rb) -> tumor formation

Question 8

gross lesions associated with papillomaviruses (4)

Answer 8

• warts
• malignant squamous cell carcinoma
• plaque-like lesions
• sarcoid

Question 9

what is the most common skin tumor of horses

Answer 9

• sarcoid