P42 - Integumentary Part 4 Flashcards
thyroid hormone is necessary for initiation of ____ stage of hair cycle
- anagen
hyperadrenocorticism (Cushing’s) have inhibitory effect on ___ synthesis and maintenance
- collagen
clinical cutaneous lesions of Cushing’s (5)
- thinning of skin (atrophic dermatopathy)
- comedones
- increased bruising
- poor wound healing
- dystrophic calcification (calcinosis cutis)
pituitary pars intermedia dysfunction (PPID) in the horse is also known as
- equine cushing’s
cutaneous lesions of equine cushing’s
- increased sweating (hyperhidrosis)
- excessively long hair coat (hirsutism or hypertrichosis)
cutaneous lesions of hyperestrogenism
- symmetric alopecia
- follicular hyperkeratosis
- enlarged nipples, prepuce, vulva
urticaria lesions are
- hives
mechanisms involved with atopic dermatitis
- type I with IgE antibodies to environmental allergens
gross lesions of insect bite hypersensitivity
- popular to exudative dermatitis and military dermatitis
insect bite hypersensitivity caused by what types
- I and IV
allergic contact dermatitis is what type of hypersensitivity
- IV
pemphigus foliaceus (PF) is also known as
- superficial pemphigus (milder and more common)
pemphigus foliaceus (PF) pathogenesis
- autoantibodies react with desmoglein 1 -> cytotoxic injury and acantholysis of superficial epidermis resulting in subcorneal pustules
pemphigus foliaceus (PF) gross and histologic lesions
- vesicles that rapidly become pustules which may be localized to face and feet
- acantholytic keratinocytes and subcorneal pustules
pemphigus vulgaris (PV) also known as
- deep pemphigus (severe)
pemphigus vulgaris (PV) pathogenesis
- autoantibodies react with desmoglein 3 -> cytotoxic injury and acantholysis of deep epidermis resulting in suprabasilar vesicles
pemphigus vulgaris (PV) gross and histologic lesions
- vesiculo-ulcerative lesions of oral mucosa, mucocutaneous junction or skin (more ulcerating)
- suprabasilar vesicles, pustules, acantholytic keratinocytes and “tombstoning”
bullous pemphigoid (BP) caused by
- autoantiodies directed against hemidesmosomal proteins -> separation of basal cells from basement membrane and subsequent subepidermal vesicle formation
bullous pemphigoid (BP) gross lesions
- vesicles
- erosions
- ulcers
- crusts
bullous pemphigoid (BP) histologic lesions
- subepidermal vesicles and bullae
systemic lupus erythematosus (SLE) pathogenesis
- formation of autoantibodies that are directed against many different cellular and soluble antigens, including nucleic acids
which form of lupus results in an elevated antinuclear antibody (ANA) titer
- systemic lupus erythematosus (SLE)
systemic lupus erythematosus (SLE) is associated with which hypersensitivity
- type III
- immune complex formation and disposition
which form of lupus results in a negative antinuclear antibody (ANA) titer
- discoid lupus erythematosus (DLE)
discoid lupus erythematosus (DLE) involves what organs
- only the skin
erythema multiforme (EM) associated with which hypersensitivity
- type IV
toxic epidermal necrolysis (TEN) can result in
- full thickness epidermal necrosis
5 examples in vet med of interface dermatopathy
- lupus erythematosus
- erythemia multiforme
- dermatomyositis
- fixed drug eruptios
- mucocutaneous pyoderma
