P42 - Integumentary Part 4

Question 1

thyroid hormone is necessary for initiation of ____ stage of hair cycle

Answer 1

• anagen

Question 2

hyperadrenocorticism (Cushing’s) have inhibitory effect on ___ synthesis and maintenance

Answer 2

• collagen

Question 3

clinical cutaneous lesions of Cushing’s (5)

Answer 3

• thinning of skin (atrophic dermatopathy)
• comedones
• increased bruising
• poor wound healing
• dystrophic calcification (calcinosis cutis)

Question 4

pituitary pars intermedia dysfunction (PPID) in the horse is also known as

Answer 4

• equine cushing’s

Question 5

cutaneous lesions of equine cushing’s

Answer 5

• increased sweating (hyperhidrosis)

- excessively long hair coat (hirsutism or hypertrichosis)

Question 6

cutaneous lesions of hyperestrogenism

Answer 6

• symmetric alopecia
• follicular hyperkeratosis
• enlarged nipples, prepuce, vulva

Question 7

urticaria lesions are

Answer 7

• hives

Question 8

mechanisms involved with atopic dermatitis

Answer 8

• type I with IgE antibodies to environmental allergens

Question 9

gross lesions of insect bite hypersensitivity

Answer 9

• popular to exudative dermatitis and military dermatitis

Question 10

insect bite hypersensitivity caused by what types

Answer 10

• I and IV

Question 11

allergic contact dermatitis is what type of hypersensitivity

Answer 11

• IV

Question 12

pemphigus foliaceus (PF) is also known as

Answer 12

• superficial pemphigus (milder and more common)

Question 13

pemphigus foliaceus (PF) pathogenesis

Answer 13

• autoantibodies react with desmoglein 1 -> cytotoxic injury and acantholysis of superficial epidermis resulting in subcorneal pustules

Question 14

pemphigus foliaceus (PF) gross and histologic lesions

Answer 14

• vesicles that rapidly become pustules which may be localized to face and feet
• acantholytic keratinocytes and subcorneal pustules

Question 15

pemphigus vulgaris (PV) also known as

Answer 15

• deep pemphigus (severe)

Question 16

pemphigus vulgaris (PV) pathogenesis

Answer 16

• autoantibodies react with desmoglein 3 -> cytotoxic injury and acantholysis of deep epidermis resulting in suprabasilar vesicles

Question 17

pemphigus vulgaris (PV) gross and histologic lesions

Answer 17

• vesiculo-ulcerative lesions of oral mucosa, mucocutaneous junction or skin (more ulcerating)
• suprabasilar vesicles, pustules, acantholytic keratinocytes and “tombstoning”

Question 18

bullous pemphigoid (BP) caused by

Answer 18

• autoantiodies directed against hemidesmosomal proteins -> separation of basal cells from basement membrane and subsequent subepidermal vesicle formation

Question 19

bullous pemphigoid (BP) gross lesions

Answer 19

• vesicles
• erosions
• ulcers
• crusts

Question 20

bullous pemphigoid (BP) histologic lesions

Answer 20

• subepidermal vesicles and bullae

Question 21

systemic lupus erythematosus (SLE) pathogenesis

Answer 21

• formation of autoantibodies that are directed against many different cellular and soluble antigens, including nucleic acids

Question 22

which form of lupus results in an elevated antinuclear antibody (ANA) titer

Answer 22

• systemic lupus erythematosus (SLE)

Question 23

systemic lupus erythematosus (SLE) is associated with which hypersensitivity

Answer 23

• type III

- immune complex formation and disposition

Question 24

which form of lupus results in a negative antinuclear antibody (ANA) titer

Answer 24

• discoid lupus erythematosus (DLE)

Question 25

discoid lupus erythematosus (DLE) involves what organs

Answer 25

• only the skin

Question 26

erythema multiforme (EM) associated with which hypersensitivity

Answer 26

• type IV

Question 27

toxic epidermal necrolysis (TEN) can result in

Answer 27

• full thickness epidermal necrosis

Question 28

5 examples in vet med of interface dermatopathy

Answer 28

• lupus erythematosus
• erythemia multiforme
• dermatomyositis
• fixed drug eruptios
• mucocutaneous pyoderma