P4 - Fluids and Vascular Disorders Part 2 Flashcards
1
Q
primary hemostasis goal
A
- platelet plug formation
2
Q
components of primary hemostasis (3)
A
- platelet adhesion to vWF
- platelet dense granule release (ADP)
- platelet aggregation
3
Q
components of secondary hemostasis (4)
A
- tissue factor released
- activates local coagulation factors
- convert prothrombin to thrombin
- fibrin forms around platelets fibrin/platelet aggregate
4
Q
pathways of coagulation (3)
A
- extrinsic
- intrinsic
- common
5
Q
antithrombotic factors (5)
A
- anti-thrombin III
- TFPI
- Protein C/S vit K dependent inhibitors of Va and VIIIa
- endothelial products inhibit platelets
- tPA
6
Q
role of anti-thrombin III
A
- binds heparin-like molecules on enothelium and platelets, inhibits IIa, Xa, and IXa localized to active site
7
Q
role of TFPI
A
- inactivates TF-VIIa complexes
8
Q
role of protein C/S vit K dependent inhibitors of Va and VIIIa
A
- IIa activates protein C
- Protein S is a cofactor for protein C
9
Q
tPA activates
A
- fibrinolysis
10
Q
hemorrhage due to abnormal function or integrity of (3)
A
- blood vessels
- platelets
- coagulation factors
11
Q
types of hemorrhage (3)
A
- petechial
- ecchymosis
- suffusive
12
Q
petechial hemorrhage
A
- due to diapedesis
- < 3mm
13
Q
ecchymosis hemorrhage
A
- damage to capillary beds
- > 1 cm
14
Q
suffusive hemorrhage
A
- hemorrhage of large areas
15
Q
factor X deficiency clinical signs
A
- severe bleeding
