P14 - Neoplasia Part 2 Flashcards
pre-neoplastic changes preceding neoplasia (4)
- hypertrophy
- hyperplasia
- metaplasia
- dysplasia
neoplasia (5)
- new growth
- tumor
- can be benign or malignant
- irreversible
- loss of responsiveness to normal growth/death controls
growth limits for benign
- limited
- circumscribed
- encapsulated
growth limits for malignant
- unrestricted
mode of growth for benign
- expansion
- pedunculation
mode of growth for malignant
- expansive
- infiltrative
metastasis of benign
- none
metastasis of malignant
- frequent
recurrence of benign
- rare
recurrence of malignant
- frequent
anaplasia of benign
- well differentiated
anaplasia of malignant
- anaplastic (poorly differentiated)
tissue structure of benign
- nearly normal
tissue structure of malignant
- abnormal
stroma of benign
- usually abundant
stroma of malignant
- usually scanty
mitotic figures of benign
- few
mitotic figures of malignant
- numerous
blood supply of benign
- usually adequate
blood supply of malignant
- adequate
tissue destruction of benign
- minimal
tissue destruction of malignant
- frequent
cellular size of benign
- uniform
cellular size of malignant
- pleomorphic
growth rate exceptions to general rule
- papillomas (benign)
- hormone dependent mammary tumors
benign non-glandular end in
- “oma”
benign glandular end in
- “adenoma”
malignant non-glandular end in
- “carcinoma”
malignant glandular end in
- “adenocarcinoma”
mesenchymal tumors are generally cells from
- connective tissue, muscle, blood cells, endothelial and related cells
- generally spindle cells in streams/bundles
teratomas
- tumor composed of multiple neoplastic tissues foreign to part which they arise
- usually benign
mixed tumor
- arise from cells that are normally found in the tissue in which they arise
- can be benign or malignant
