P30 - Hepatobiliary and Exocrine Pancreas Part 4

Question 1

what type of liver neoplasia is more common in cats

Answer 1

• biliary

Question 2

cystadenoma

Answer 2

• benign biliary neoplasm

Question 3

cholangiocarcinoma

Answer 3

• malignant biliary neoplasm

Question 4

lymphoma in the liver can be hard to see, why

Answer 4

• enlarged and lobes are very rounded

Question 5

what are the 2 most common sites of metastasis

Answer 5

• liver and lung

Question 6

T/F: liver disorders in the horse are common

Answer 6

• false - are uncommon

Question 7

equine serum hepatitis also known as

Answer 7

• theiler’s disease

Question 8

equine serum hepatitis occurs after and results in

Answer 8

• receiving injection of biologic that contains equine serum
• fatal acute hepatic failure

Question 9

gross appearance of equine serum hepatitis

Answer 9

• livers are small
• flabby
• discolored greenish-brown

Question 10

histologic lesions of equine serum hepatitis

Answer 10

• diffuse centrilobular necrosis

Question 11

intravascular hemolysis is present at what stage of equine serum hepatitis

Answer 11

• late stage

Question 12

infectious necrotic hepatitis is also known as

Answer 12

• black disease

Question 13

infectious necrotic hepatitis is most common in

Answer 13

• sheep and cattle

Question 14

infectious necrotic hepatitis caused by

Answer 14

• clostridium novyi

Question 15

pathogenesis of infectious necrotic hepatitis

Answer 15

• clostridium novyi spores lies dormant in Kupffer cells -> germinate in areas of hepatic necrosis (fluke migration) -> bacterial exotoxins cause hepatocellular necrosis

Question 16

bacillary hemoglobinuria is caused by

Answer 16

• clostridium haemolyticum

Question 17

pathogenesis of bacillary hemoglobinuria

Answer 17

• bacterial spores of clostridium haemolyticum ingested -> migrate through portal circulation to liver
• with hepatic necrosis and hypoxia -> spores germinate -> produce exotoxins -> hepatocellular necrosis, intravascular hemolysis, anemia, hemoglobinuria

Question 18

white liver disease due to

Answer 18

• sheep with nutrition deficiency of cobalt

Question 19

vitamin B12 deficiency can lead to

Answer 19

• severe anemia and subsequent centrilobular hepatocellular necrosis and liver failure

Question 20

hepatosis dietetica occurs in

Answer 20

• young and rapidly growing pigs (have high nutritional demands)

Question 21

hepatosis dietetica is acute hepatic necrosis associated with

Answer 21

• vitamin E and/or selenium deficiency -> oxidative injury

- can lead to white muscle disease

Question 22

cresol toxicity (clay pigeons and asphalt shingles) results in

Answer 22

• centrilobular to massive hepatocellular necrosis

Question 23

2nd most common liver disease in cats

Answer 23

• feline inflammatory hepatobiliary disease (disease of biliary tree)

Question 24

cats suffering from lymphocytic cholangitis may present

Answer 24

• lethargy
• inappetence
• weight loss
• icterus

Question 25

main differential diagnosis fo lymphocytic cholangitis

Answer 25

• lymphoma

Question 26

how do you distinguish lymphocytic cholangitis from suppurative cholangitis

Answer 26

• lymphocytic is responsive to immunosuppressive therapy

- suppurative will get worse is given immunosuppressive

Question 27

neutrophilic cholangitis also known as

Answer 27

• suppurative cholangitis

Question 28

suppurative cholangitis is due to

Answer 28

• ascending bacterial infection