P11 - Inflammation Part 6 Flashcards
inflammation with overlap of neutrophils, fibrin deposition, clotting, cytokines and other factors
- acute inflammation
inflammation with overlap of macrophages, granulation tissue, cell repopulation
- chronic inflammation
inflammation with overlap of neutrophils, macrophages, fibrin deposition, clotting, granulation tissue, cell repopulation
- recurrent inflammation
2 mechanisms of healing
- healing by regeneration
- healing by repair
dead cells are replaced by identical cell type and tissue homeostasis is restored or near-restored
- superficial cut
- healing by regeneration
dead cells must be replaced by another cell type (usually fibrous)
- deeper cut
- healing by repair
cell types involved that determine type of healing (3)
- labile cells
- stabile cells
- permanent cells
labile cells
- highly regenerative capacity
- regenerate for life
- cells with high turnover
small intestine, bone marrow, GI and skin are all what type of cells
- labile
stabile cells
- regenerative capacity when stimulated
- cells of parenchymatous organs
- regenerative capacity decreases with age
liver, kidney, pancreas, adrenal, bone, tendon, nerve and smooth muscle are all what type of cells
- stabile
permanent cells
- little to no regenerative capacity
- healing occurs by replacement with scar tissue
skeletal and cardiac muscle, cells in central nervous system are all what type of cells
- permanent
hallmark of chronic inflammation
- granulation tissue
features of granulation tissue
- arrises from healthy tissue at periphery of wounds and matures to scar tissue
- comprised of new blood vessels and new fibroblasts
- deposition of each in crisscross pattern
- matures into fibrous connective tissue
stimulation of new blood vessels
- angiogenesis
stimulation of fibroblasts (3)
- injured cells and immune cells secrete growth factors
- fibroblasts migrate into wound from progenitor cells from tension lines
- fibroblasts produce collagen
TGF-beta stimulates
- fibroblast cell proliferation and differentiation
IL-1 is what for fibroblasts
- chemotaxic
exuberant granulation tissue
- hyperplasia of granulation tissue (tumor-like)
steps of primary union (6)
- clot formation
- inflammatory response
- fibroblast and endothelial response
- continuity of blood flow
- epithelial regeneration
- collagen formation
steps of secondary union (4)
- phagocytosis of debris (cleaning of wound)
- granulation tissue comes from wound margins
- deficit begins to be filled by granulation tissue
- maturation to fibrosis and contraction by myelofibroblasts
