Myeloproliferative Disorders Flashcards

1
Q

What are myeloproliferative disorders?

A

Uncontrolled proliferation of a single type of stem cell

Considered a form of cancer occurring in the bone marrow, developing and progressing slowly.

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2
Q

What potential transformation can myeloproliferative disorders undergo?

A

Acute myeloid leukaemia

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3
Q

Name the main types of myeloproliferative disorders.

A
  • Primary myelofibrosis
  • Polycythaemia vera
  • Essential thrombocytopenia
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4
Q

What are the blood results associated with primary myelofibrosis?

A
  • Low haemoglobin
  • High or low WCC
  • High or low platelets
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5
Q

What are the blood results associated with polycythaemia vera?

A
  • High haemoglobin
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6
Q

What are the blood results associated with essential thrombocytopenia?

A
  • High platelets
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7
Q

What is a common causative mutation in myeloproliferative disorders?

A

JAK2

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8
Q

What does myelofibrosis lead to in the bone marrow?

A

Bone marrow fibrosis

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9
Q

What are the results of bone marrow fibrosis?

A
  • Anaemia (low haemoglobin)
  • Leukopenia (low white blood cells)
  • Thrombocytopenia (low platelets)
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10
Q

What is extramedullary hematopoiesis?

A

Production of blood cells in areas outside the bone marrow due to fibrosis

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11
Q

What are the potential effects of extramedullary hematopoiesis in the liver and spleen?

A
  • Hepatomegaly
  • Splenomegaly
  • Portal hypertension
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12
Q

What are the blood film characteristics in myelofibrosis?

A
  • Teardrop-shaped red blood cells
  • Anisocytosis
  • Blasts (immature red and white cells)
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13
Q

List some non-specific symptoms of myeloproliferative disorders.

A
  • Fatigue
  • Weight loss
  • Night sweats
  • Fever
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14
Q

What are signs of complications in myeloproliferative disorders?

A
  • Anaemia (tired, SOB, dizzy)
  • Splenomegaly (abdo pain)
  • Portal hypertension (ascites, varices, abdo pain)
  • Low platelets (bleeding and petechiae)
  • Raised haemoglobin (itching, headaches, red face)
  • Low white cells (infection)
  • Gout (complication of polycythaemia)
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15
Q

What are some features of polycythaemia?

A
  • Ruddy complexion (red face)
  • Conjunctival plethora
  • Splenomegaly
  • Hepatomegaly
  • Complication → thrombosis
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16
Q

What is the primary method for diagnosing myeloproliferative disorders?

A

Bone marrow biopsy

17
Q

What might the aspirate from a bone marrow biopsy show in myelofibrosis?

A

Dry aspirate due to scar tissue

18
Q

What testing is done for diagnosing JAK2 mutations?

A

Testing for JAK2 genes

19
Q

What are the management strategies for primary myelofibrosis?

A
  • Supportive care
  • Chemotherapy (e.g., hydroxycarbamide)
  • Targeted therapies (e.g., JAK2 inhibitors - ruxolitinib)
  • Allogenic stem cell transplant
20
Q

What management strategies are used for polycythaemia vera?

A
  • Venesection
  • Aspirin
  • Chemotherapy (e.g., hydroxycarbamide)
21
Q

What are the management strategies for essential thrombocytopenia?

A
  • Aspirin
  • Chemotherapy (e.g., hydroxycarbamide)
  • Anagrelide
22
Q

How to differentiate myeloproliferative disorders with myelodsplatic syndromes?

A

Myeloproliferative - MPD (P - proliferate, too many MATURE cells)
Myelodysplastic - MDS (D - dysfunctional, too many IMMATURE or faulty cells)
Both are myeloid affecting.
Myelodysplastic has > blasts so more chance developing into AML.