Myasthenia Gravis Flashcards
What is the primary aetiology of myasthenia gravis?
Autoimmune response leading to the production of antibodies against acetylcholine receptors.
Name one common clinical feature of myasthenia gravis.
Muscle weakness that worsens with activity and improves with rest.
What is the hallmark symptom of ocular myasthenia gravis?
Ptosis (drooping of one or both eyelids).
Fill in the blank: Myasthenia gravis can lead to __________, which is characterized by respiratory muscle weakness.
myasthenic crisis
Which diagnostic test is commonly used to confirm myasthenia gravis?
Serological tests for acetylcholine receptor antibodies.
What imaging study can be used to identify thymoma in patients with myasthenia gravis?
Chest CT scan.
True or False: Edrophonium chloride can be used as a diagnostic tool in myasthenia gravis.
True
List one first-line treatment option for myasthenia gravis.
Anticholinesterase medications such as pyridostigmine.
What is the role of corticosteroids in the management of myasthenia gravis?
To reduce immune system activity and inflammation.
What surgical intervention may be indicated for patients with thymoma or generalized myasthenia gravis?
Thymectomy.
Fill in the blank: __________ is a serious complication of myasthenia gravis that requires immediate medical attention.
Myasthenic crisis
What is a potential long-term complication of untreated myasthenia gravis?
Chronic respiratory failure.
True or False: Myasthenia gravis can occur in conjunction with other autoimmune diseases.
True
What is the significance of repetitive nerve stimulation in the investigation of myasthenia gravis?
It can demonstrate a decremental response in muscle action potentials.
Name one immunosuppressive therapy used in the management of myasthenia gravis.
Azathioprine.
What symptom is associated with bulbar involvement in myasthenia gravis?
Dysphagia (difficulty swallowing).
Which age group is most commonly affected by myasthenia gravis?
Women under 40 and men over 60.
Fill in the blank: The presence of __________ antibodies is associated with a poorer prognosis in myasthenia gravis.
muscle-specific kinase (MuSK)
What is one of the first symptoms that may present in a patient with myasthenia gravis?
Diplopia (double vision).
