Coeliac Disease Flashcards
1
Q
Coeliac disease
A
Complex, autoimmune condition triggered by eating gluten.
Close association with type 1 diabetes and thyroid disease.
2
Q
Auto-antibodies associated with coeliac disease
A
Anti-TTG
Anti-EMA
Anti-DPG
3
Q
Characteristic biopsy findings in coeliac disease
A
Small bowel (often jejunum)
- crypt hypertrophy
- villous atrophy
- increased lymphocyte cells
4
Q
Alleles linked to coeliac disease
A
HLA- DQ2
HLA-DQ8
5
Q
Clinical features of coeliac disease
A
- failure to thrive
- weight loss
- diarrhoea/steatorrhoea
- bloating
- abdo pain
- anaemia - iron, b12, folate
- mouth ulcers
- dermatitis herpetiformis
6
Q
Diagnosing coeliac disease
A
bloods:
- IgA levels
- ant-TTG
if +ve -> biopsy
7
Q
Managing coeliac disease
A
Lifelong gluten free diet
supplements
