Mod4: extrinsic coagulation cascade Flashcards
1
Q
Coagulation factors produced in
A
liver
2
Q
extrinsic factor activated when
A
tissue is injured (tissue factor 3 exposure)
factor 3 has a receptor for factor 7, binded= TF/VIIa complex
3
Q
TF/VIIa complex activates __
which binds to ____ and ___= prothrombinase complex
A
X=Xa
which binds to Va and calcium =prothombinase complex
4
Q
Prothrombinase complex converts ___ to ____
A
converts prothrombin (factor 2) to thrombin (factor 2a)
5
Q
Thrombin (2a) activates 4 factors
A
fibrinogen (factor 1)->fibrin (1a)
5, 8, 13
6
Q
what stabilizes platelet plug
A
fibrin (1a) and factor 13a
