Mod 8: thyroid

Question 1

___ regulates thyroid hormone secretion

Released by __

Answer 1

TSH

anterior pituitary

Question 2

T3 and T4 differences

Answer 2

T3 more portent/ short lived, less in blood (10%)

T4 (90%)

Question 3

T3 and T4 bound to tansport proteins ____ or ____

Prior to entering nucleus what happens

Answer 3

albumin or thyroxine-binding globulin (TBG)

T4 converted to T3 in cell before entering nucleus

Question 4

Iodine used to form ___, takes ____/wk

• trapped by
• uptake is regulated by

Answer 4

thyroxine, 1mg/wk
thyroid gland
regulated by TSH

Question 5

Thyroglobulin is a precursor to ___,___

Enough is stored to last ___ before sx start

Answer 5

T3 and T4

2-3 months

Question 6

what stimulates thyroid to release more T3 and T4

v__=___factor=___=T3/T4

Answer 6

vThyroid hormone = release of thyroid releasing factor = TSH released = Thyroid release of T3 and T4

Question 7

T3 T4 functions

March frog cclr

Answer 7

muscle tone/maturation
antagonization of insulin
regulate cell metabolism
cardiac output/contraction/rate
heat production
Free fatty acid release
Respiratory rate 
O2 utilization 
Gi secretions
calcium mobilization
lipid metabolism
cholesterol synthesis 
RBC production

Question 8

T3 in heart stimulates
contractile protein ___, ___ion pumps, ___receptors

hyperthyroid can = HF how

Answer 8

Contractile protein a-mysosin
-Sarcolemma ion pumps
B-adrenergic receptors
=hf by ^HR, CO, =cardiomyopathy

Question 9

Calcitonin secreted by ___ cells of thyroid

lowers ca by blocking ______ (prevents bone resorption of __,___,__)

Answer 9

c-cells

blocks osteoclastic activity (prevents bone resorption of PTH, prostandlandins, and calciferols)

Question 10

Calcitonin ___ phosphate levels, and decreasing _____ absorption of ca / phos

Answer 10

lowers phosphate levels

decreases GI absorption of Ca/ phos

Question 11

An over secretion of thyroid hormone can be caused by __,__, and ___

Answer 11

graves, CA, nodules

Question 12

Hyperthyroid s/s

SHARP HEFT SWIG BH

Answer 12

Anorexia, Weight loss, Irreg period, BM’s^
vAttention span,Restless, Fine tremor, Hair loss
Tachycardia, HF
Heat intolerance, sweats
Exopthalmos, Pretibial edema
goiter

Question 13

Hyperthyroid labs will show

Answer 13

low tsh, high free T4

Question 14

Most common cause of Hyperthyroid

Autoimmune and more common in

Answer 14

Graves disease more common in women

Question 15

Graves Disease
Thyroid stimulating antibodies attach to thyroid cells and mimic the function of ___=^___, ___= overrides _____ which regulates ____secretion

Answer 15

mimic function of TSH= ^T3 T4 overriding the negative feedback mechanisms regulating TSH secretion

Question 16

Graves development of Goiter is d/t stimulation of _____ by _____
other s/s (3)

Answer 16

stimulation of receptors by antibodies

exopthalmis, periorbital edema, extraocular muscle weakness=strabismus and diplopia

Question 17

Thyroid nodules can= _____, and secrete extra ______
Formed by follicular ____ of thyroid cells
develop d/t ____changes, ___ issue, ___,___

Answer 17

hyperthyroidism, secrete extra thyroid hormones
follicular hypertrophy of thyroid cells,
develop d/t normal preg/puberty changes, autoimmune issue, viral infection, genetics

Question 18

Thyroid nodule hyperthyroid s/s develop ___

do not experience ___ or ___

Answer 18

slowly

do not have exopthalmos and pretibial myxedema

Question 19

Thyroid storm  (thyrotoxic crisis)=dangerous worsening of \_\_\_\_
if untreated= \_\_\_
triggered by (6) or spontaneous

Answer 19

hyperthyroid state
death
trauma, burns, cardiopulmonary disorders, seizures, surgery, infection

Question 20

Thyroid storm s/s (10) caused by sudden release of hormones

Answer 20

restless, agitated, delirium, seizures, coma, tachycardia, HF, hyperthermia, volume depletion, n/v/d