Mod3: Inflammation

Question 1

1.Mast cell degranulation activates___

Releases 5:

Answer 1

Activates acute phase reactants (coag,kinin, complement cascade)
histamine
cytokines
leukotrines
platelet activating factor
prostaglandins

Question 2

Histamine1 causes ____, ____,___

released by mast cell degranulation

Answer 2

vasodilation, ^vascular permeability (red/swollen)

bronchoconstriction

Question 3

Histamine2
In ___ =______
Target for

(Released by mast cell degranulation)

Answer 3

anti-inflammatory
in gastric mucosa
normally=excretion of gastric acid
target for ranitidine, tagamet, famotidine

Question 4

Cytokines
TNF
IL13
IL4

(Released by Mast cell degranulation)

Answer 4

TNF: leukocyte emigration, ^vascular permeablity (early and late)
IL-13:chemotaxis, B-cell/antibody production (later)
IL4:B-cell/antibody production (early)

Question 5

Leukotrines aka ____
____ inflammatory response

Attract 3

(Target for singular)
(Released by mast cell degranulation)

Answer 5

slow reaction substances of anaphylaxis (SRS-A)
prolong inflammatory response

attract neutrophils, monocytes, and eosinophils

Question 6

Prostaglandins

Produced in ____ pathways

Causes 4
(released from mast cell degranulation)

Answer 6

produced in arachidonic pathway
vasodilation
platelet aggregation
pain
fever

Question 7

5.Release of chemotactic factors
Attract ___,___,___ responsible for ____
Release contents=

Answer 7

Attract neutrophils, eosinophils, and monocytes responsible for phagocytosis

Die and release contents trigger acute phase reactants

Question 8

Leukocytes after phagocytosis

__ and ____ =triggers ____

Answer 8

Die, release contents (pus)

=acute phase reactants

Question 9

monocytes

(Attracted to release of chemotactic factors)

Release ___

Answer 9

become macrophages when entering tissue
Present antigens to CD4 cell=triggers Tcell immunity->triggers Bcell immunity

Release cytokines

Question 10

3. Complement cascade

Answer 10

most potent defenders, esp w bacteria

Bacterial lysis
Vasodilation,^vascular permeability
Triggers mast cell degranulation
^Chemotaxis/ ^Opsonization

Question 11

4. Kinin Cascade
   Turned into ____ = ___,___,____
   Responsible for ___

Answer 11

Turned into bradykinin =pain, ^vascular permeability, vasodilation
Responsible for chemotaxis

Question 12

2. Coagulation Cascade activates ___

Forms___

Answer 12

Activates kinin system XII (hageman)
Forms fibrin mesh to stop bleeding and trap microorganisms

Activated by many substances released during tissue injury/infection

Question 13

Platelet activating factor
produced by 3 and ___,____

Causes ___, ___,_____

(Produced by mast cell degranulation)

Answer 13

produced by neutrophils, monocytes, endothelial cells, plts, fatty acids
^cell retraction,^vascular permeability ^leukocyte adhesion to endothelial cells

Question 14

Monocytes release 4

Attracted to site d/t chemotactic factors

Answer 14

IL1:fever, phagocytes
IL6: acute phase reactants, blood cell growth
TNF:fever, ^proinflammatory proteins in liver, muscle wasting, thrombosis
Growth factors: mature neutrophils