Mod 4: intrinsic coagulation cascade

Question 1

intrinsic activated by

Answer 1

ADP ATP negative charges activates factor X12 (hageman), which activates 11->9 ->10->forms prothrombinase

Question 2

Carboxylation needed for what

change in ___ to ____

Answer 2

needed to mature vitamin K dependent coagulation factors

change of glutamate to Ycarboxyglutamate

Question 3

K dependent proteins

Answer 3

factors 2, 7, 9, 10, protein C&S

Question 4

Vitamin K needed with carboxylase to complete ____

Answer 4

complete carboxylation

Question 5

Warfarin works how
=^___
also inhibits ____ and ____
initially causes a ______

Answer 5

blocks coding for K oxide reductase =vK available
=^PT
also inhibits protein s/c, intially causes hypercoagulable state

Question 6

Pt measures

Prolonged w

Answer 6

PT-extrinsic and common pathway

prolonged w vK, liver disease, 2,5,7

Question 7

PTT measures

prolonged ptt caused by

Answer 7

intrinsic pathway, 12, 11, 9, 8
common pathway 2, 5, 10, 1
any deficiency except 7 can = prolonged ptt

Question 8

tPA released in response to

activates

Answer 8

thrombin , epi, cytokines, sertonin, bradykinin

activates plasminogen

Question 9

plasminogen activates____ which dissolves ____, ____, ____, ____

Answer 9

activates plasmin, dissolves fibrin, fibronectin, vWF, thrombospondin

Question 10

Low molecular weight heparin targets
prevents formation of ____ and consequently ____
same factor ___ inhibitors

Answer 10

activated 10
prevents formation of prothrombinase complex and consequently thrombin
same w factor Xa inhibitors

Question 11

thrombin inhibitors

Answer 11

prevents activation of fibrinogen ->fibrin (supports plt plug) and XIII ->XIIIa( links w fibrin to stabilize plug)