Medical Management of Degenerative Joint Disease Flashcards
what happens in the intimal layer of the synovium?
phagocytosis: type A synoviocytes
protein synthesis: type B synoviocytes
why are changes in synovial fluid properties a problem?
less effective boundary lubrication of soft tissues
what are some commonly used medications?
NSAIDs
corticosteroids
hyaluronan
nutriceuticals
orthobiologics
what does interleukin-1 do?
major mediator of cartilage degeneration and destruction
what are the indications for IRAP?
mild to moderate osteoarthritis
capsulitis/synovitis
post-arthroscopic exploration
OCD post-op
post septic arthritis?
what does the subintimal layer do?
blood supply
innervation
what does articular cartilage lack?
vascular, lymphatic, neural supply
relies on synovial fluid for nutrients and waste removal
________________ predominance leads to degenerative joint disease
catabolic
why are changes in synovial fluid properties a problem in joint disease?
reduction in synovial fluid properties
altered cartilage nutrition
less effective boundary lubrication to soft tissues
what can we do to decrease degenerative joint disease?
slow down progression
keep what’s healthy
create/repair tissue as close to normal as possible
reduce inflammation
return catabolic:anabolic ratio
intra-articular vs systemic therapy
what are some NSAIDs?
phenylbutazone
flunixin
surpass: 1% diclofenac sodium
cyclooxygenase inhibitors
what corticosteroids are used?
methylprednisolone acetate/depo medrol
triamcinolone/vetalog
betamethasone/betavet/soluspan
isoflupredone acetate/predef
which corticosteroid has potential chondroprotective properties?
triamcinolone/vetalog
which corticosteroid is long acting?
methylprednisolone acetate
what is IA hyaluronan?
mild anti-inflammatory
legend
