Equine Viral Respiratory Disease Flashcards
who is most affected by viral infections?
young and old
what are the risk factors for viral disease?
stocking density
lack of prior exposure
exercise?
how does intense exercise affect immunity?
oxidative stress
changes in catecholamine release
cytokine release and activity
decreased secretion of mucosal antibodies
decreased functional activity of blood and pulmonary leukocytes
what viruses cause respiratory disease in the USA?
equine influenza AE2
equine herpesvirus 1, 2, 4, 5
equine rhinitis virus
equine viral arteritis
adenovirus
hendra virus- exotic disease Australia
what type of virus is influenza?
orthomyxovirus: double stranded RNA
what is onset like of influenza?
sudden onset
incubation period 1-3 days
how can you diagnose equine influenza virus?
serology: slow
virus isolation: slow and false positives
ELISA: fast
PCR: fast- 36 hours
when should you sample for virus isolation?
early in disease
how can you treat equine influenza virus?
rest
good nursing care
NSAIDs
monitor clinical signs for secondary bacterial pneumonia and treat as needed
when should you think about a secondary bacterial infection with viral disease?
non-resolving fever
purulent nasal discharge
difficulty breathing
what is antigenic drift like?
big changes in chunks of RNA
can jump species
what are the two main variations of herpesviruses?
alpha
gamma
what can amplify and maintain virus reservoir of herpesvirus?
latent dam to foal
viral latency in foals/weanlings
periodic reactivation and shedding
what is the clinical presentation like of equine herpesvirus 1 and 4?
similar to every other respiratory virus
EHV-1 neurologic disease and abortion too
what are the gamma herpesviruses?
EHV-2
EHV-5