Equine Pneumonia and Pleuropneumonia Flashcards

1
Q

what are the clinical signs of pneumonia?

A

fever
tachypnea
nasal discharge
coughing
exercise intolerance

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2
Q

what can be seen on a CBC with fibrinogen with equine pneumonia?

A

neutrophilic leukocytosis +/- left shift
severe/early: neutropenia with toxic left shift
fibrinogen almost always elevated

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3
Q

what is the normal defense system?

A

mucociliary clearance
phagocytic cells
cellular and humoral immune system

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4
Q

what can aspiration be due to?

A

anesthesia
esophageal obstruction/choke
reduced laryngeal function

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5
Q

how do viral diseases impact the respiratory epithelium?

A

enhanced susceptibility to bacterial attachment
diminished mucociliary function
decreased surfactant: type II cells destroyed

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6
Q

how can you treat equine pneumonia?

A

antimicrobials based on culture and sensitivity
anti-inflammatories
anti-endotoxic
consider oxygen if hypoxia- foals

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7
Q

what antibiotics have the lowest relative drug concentration in lung secretions?

A

penicillins

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8
Q

what does most severe bronchopneumonia havee?

A

element of pleural inflammation

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9
Q

what is the pleural fluid like initially with pleuropneumonia?

A

sterile fluid

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10
Q

what should you do when ultrasounding a horse’s chest?

A

look at both sides, full chest
measure amount of fluid
look at mediastinum

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11
Q

should you sample the pleuropneumonia before placing the horse on antibiotics?

A

yes

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12
Q

what should you sample in pleuropneumonia?

A

trachea
pleural fluid
both: different organisms may grow

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13
Q

what is the most important predisposing factor for pleuropneumonia?

A

“shipping fever”: transport

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14
Q

what is required for any shot to return to athletic career in horses with pleuropneumonia?

A

aggressive, early treatment

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15
Q

when is the prognosis poorer with pleuropneumonia?

A

anaerobes
significant fibrin accumulation
hepatized lung
laminitis

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16
Q

what is pneumonia?

A

pulmonary defense mechanisms reduced
bacterial invasion and multiplication
inflammatory cells influx
parenchymal disease
possible extension into pleural space

17
Q

what can be seen on the chemistry profile with pneumonia?

A

high globulins
check creatinine

18
Q

what happens with serum amyloid A in pneumonia?

A

markedly elevated

19
Q

what are the risk factors for pneumonia?

A

cold temperature
transportation
exercise-induced pulmonary hemorrhage
aspiration

20
Q

how does transportation increase the risk of pneumonia?

A

poor ventilation
reduced mucociliary clearance
overcrowding

21
Q

why does it matter that viral diseases denude respiratory epithelium?

A

enhances susceptibility to bacterial attachment
diminishes mucociliary function
decreases surfactant because type II cells destroyed

22
Q

what is the common gram negative anaerobe that causes pneumonia?

A

Prevotella

23
Q

how should you choose antibiotics?

A

broad spectrum
good penetration
consider pharmacokinetics of specific organism you are targeting, as well as what is feasible long term

24
Q

what is the penetration of aminoglycosides in the lungs?

A

20-30%

25
Q

what is the penetration of enrofloxacin in the lungs?

A

70%
also accumulates in alveolar macrophages: great

26
Q

what drug should you use for anaerobic infection?

A

metronidazole
also 100% lung penetration

27
Q

what can pleuropneumonia organize into?

A

pleural abscessation

28
Q

where should you sample for pleuropneumonia?

A

transtracheal aspirate
pleural tap bilaterally

29
Q

how does transport predispose to pneumonia?

A

depresses alveolar macrophages
depresses neutrophil respiratory burst
prevents postural drainage with bacterial colonization
high exposure to dust particles