Gastrointestinal Disease of the Horse Part III Flashcards

1
Q

what is colitis?

A

inflammatory condition involving the large colon
disruption of normal fluid and electrolyte secretion and absorption

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2
Q

what is the most prominent sign of colitis?

A

diarrhea

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3
Q

what are the risk factors for salmonella?

A

antimicrobial administration
gastrointestinal disease
transportation
high density confinement
high intensity training

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4
Q

what are the clinical signs of salmonella?

A

fever
lethargy
diarrhea
abdominal discomfort

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5
Q

what is the treatment of salmonella?

A

mostly supportive
antibiotics if evidence of sepsis

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6
Q

when are clinical signs usually seen with coronavirus?

A

2-8 days after infection

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7
Q

how long may horses with coronavirus continue to shed virus?

A

several weeks

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8
Q

what causes potomac horse fever?

A

Neorickettsia risticii

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9
Q

what is potomac horse fever carried by?

A

aquatic snails
water insects

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10
Q

what percentage of horses with potomac horse fever get laminitis?

A

25%

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11
Q

how is Clostridium difficile treated?

A

metronidazole
fecal microbiota transplantation

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12
Q

what can blister beetles be incorporated into?

A

baled alfalfa hay

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13
Q

what is the pathogenesis of right dorsal colitis?

A

unknown
inhibition of prostaglandin E production
hypoxic ischemic mucosal damage

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14
Q

what is the drug of choice for potomac horse fever?

A

oxytetracycline

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15
Q

disruption of the microbial balance of the gut for any reason may result in colitis due to ____________________

A

colonic dysbiosis

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16
Q

when does foal heat diarrhea often occur?

A

10 days of age

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17
Q

what are affected foals with foal heat diarrhea like?

A

BAR
afebrile
continue to nurse

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18
Q

what is the pathogenesis of foal heat diarrhea?

A

alterations in foal’s intestinal microbial flora
diet changes as foal begins to eat hay and grain
not associated with hormonal changes in mare or changes to milk

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19
Q

in which foals does rotavirus cause disease?

A

<4 weeks of age

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20
Q

how is Strongyloidess westeri shed to a foal?

A

through mare’s milk to foal

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21
Q

are systemic antibiotics indicated in foals with acute colitis?

A

often: treat bacteremia

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22
Q

what does Lawsonia intracellularis cause?

A

proliferative enteritis
most common in ileum

23
Q

what is the predominant sign of eosinophilic enterocolitis?

A

colic

24
Q

how can you diagnose inflammatory bowel disease?

A

ultrasound examination
endoscopic/rectal biopsies
absorption test

25
Q

what is the most common gastrointestinal neoplasm?

A

lymphoma

26
Q

has lymphoma been associated with viral etiology in horses?

A

no

27
Q

what are the potential complications of colitis?

A

laminitis
multi-organ dysfunction, coagulopathy
peripheral edema

28
Q

what is incidence like of salmonella in non-hospital settings?

A

low

29
Q

how can you diagnose salmonella?

A

5 separate cultures of feces for salmonella
PCR, 3 samples

30
Q

what are the clinical signs of coronavirus?

A

anorexia, lethargy, high fever most common
colic, diarrhea
necrotizing enteritis possible

31
Q

what are the risk factors for potomac horse fever?

A

aquatic environments
summer months

32
Q

what carries potomac horse fever?

A

aquatic snails
water insects

33
Q

what are the clinical signs of potomac horse fever?

A

fever
anorexia
depression
diarrhea
laminitis 25%

34
Q

is there vaccine available for potomac horse fever?

A

yes- killed

35
Q

what is Clostridium difficile associated with?

A

acute colitis, especially in hospitalized horses
relationship to antibiotic treatment

36
Q

how can you diagnose Clostridium difficile?

A

quantitative culture
PCR toxigenic isolates in feces
ELISA for toxin A and/or B

37
Q

what is the lethal dose of cantharidin?

A

<1mg/kg
6-8 beetles

38
Q

what does cantharidin cause?

A

ulceration of GI, cystitis, nephrosis, myocarditis
hypovolemia, hypoalbuminemia, hypocalcemia, azotemia

39
Q

do measures levels of cantharidin correlate with disease severity?

A

no

40
Q

what is right dorsal colitis associated with?

A

NSAID administration
phenylbutazone

41
Q

how can you counteract the effects of endotoxemia?

A

anti-endotoxic doses banamine, polymixin, endoserum
anti-diarrheal medication
prevent sequelae/complications

42
Q

what types of Clostridium usually do not cause clinical signs in foals?

A

Clostridium perfringens types A and C

43
Q

what does rotavirus do?

A

destroys absorptivee villous epithelial cells: malabsorption
secretory function due to hyperplasia crypt cells- compensatory

44
Q

how common is Cryptosporidium parvum in horses?

A

rare
immune deficiency

45
Q

how can you treat acute colitis in foals?

A

systemic antibiotics
fecal microbiota transplantation
lactaid in lactase deficiency
goal directed fluid therapy
vasopressors if needed

46
Q

who is Lawsonia intracellularis usually seen in?

A

weanlings

47
Q

what are the clinical signs of Lawsonia intracellularis?

A

significant hypoproteinemia
anorexia
weight loss
lethargy
fever

48
Q

how can you treat Lawsonia intracellularis?

A

clarithromycin and rifampin
doxycycline
chloramphenicol

49
Q

what are the three types of inflammatory bowel disease?

A

granulomatous enteritis
lymphocytic/plasmocytic enteritis
eosinophilic enterocolitis

50
Q

what is the predominant sign in IBD eosinophilic enterocolitis?

A

colic

51
Q

what is seen in histopathology with IBD eosinophilic enterocolitis?

A

circumferential mural bands of fibrous tissue

52
Q

when is the prognosis poor with inflammatory bowel disease?

A

if not responsive to glucocorticoids

53
Q

who does lymphoma typically occur in?

A

<5 years old

54
Q

what is survival with lymphoma?

A

<6months even with treatment usually