Lecture 47 - ALT Virology 2 Flashcards
what are the 2 subfamilies of parvovirinae
- parvoviridae (vertebrates)
2 pneumovirinae
how is feline panleukopenia virus transmitted
- direct contact
- fleas/humans are vectors
- fomites
what are the clinical signs of FPV
bloody D+, V+, dehydration, painful belly, anemia
in all ages, kittens severely affected
summarize the pathogenesis of FPV
- ingestion/inhalation
- replication in oropharynx lymphoid tissue
- infection of cells of intestinal crypts
- panleukopenia and intestinal villi atrophy
*transplacental can cause cerebellar hypoplasia
how is FPV controlled
MLV
describe type 1 and type 2 canine parvovirus
type 1 - isolated in dog feces, not major cause of disease
type 2 - severe GI illness, highly contagious w/ enteritis, myocarditis, lymphopenia
how is CPV transmitted
- exposure to feces and other bodily fluids
- fomites
summarize CPV pathogenesis
- ingestion
- infection of tonsils and laryngeal lymph nodes
- replication in lymphocytes
- infection/destruction of intestinal crypts
- villi atrophy
Describe Canine Distemper Virus
- highly contagious
- clincal cases seen in unvaccinated dogs/wildlife
- causes acute febrile disease
how are CDV transmitted
- shed in all secretion/excretion 5-7days after infection
- aerosol
T/F: as maternal antibody wanes, puppies 4-6 m/o are most susceptible to CDV
TRUE
T/F: CDV has a tropism for GI cells
FALSE
summarize the CDV pathogenesis
- virus replicates in lymph tissue of respiratory tract
- viremia causes infection of all lymph tissue
- GI and CNS infection
how is CDV controlled
VAX
what are the genera of calciviridae
- vesivirus (marine/vesicular)
- Norovirus
3 Lagovirus - Unclassified
Describe the generals of feline and canine norovirus
- spread fecal-oral
- large diversity of strains
- Reinfection can occur
- high prevalence in shelters
- recombination of feline and canine strains
Describe Rabbit Hemorrhagic Disease Virus (RHDV)
causes viral hepatitis in rabbits, but does not affect other animals due to tropism
T/F: RHDV was used as a biological control agent in Australia
TRUE
what is the current strain of RHDV of concern? is there a vaccine available?
RHDV2; yes
what disease is apparent with infectious pancreatic necrosis virus
- highly contagious
- disease in young salmonid fish
- lifelong carriers
- swollen abdomen, bulging eyes, cutaneous hemorrhage
- viral necrosis of pancreas on necropsy
summarize the pathogenesis of infectious bursal disease
- oral entry
- replication in gut-associated macrophages and lymphoid cells
- enteric infection (D+)
- primary viremia
- bursal lymph node spread compromises immune system
- secondary viremia
- immune complex deposit in kidneys
are primary or secondary infections of IBDV worse
primary
secondary has maternal antibody protection
T/F: vaccines are not available for IBDV
FALSE
describe chicken proventricular necrosis virus
enlargement of proventriculus with tendency to rupture at production causing contamination and major economic loss
