Lecture 4 - Cardio virology 2 Flashcards
what are the avian oncogenic retroviruses of veterinary importance
avian leukosis and sarcoma virus
how many groups of avian leukosis viruses are there
7 groups (A through G)
what groups of avian leukosis infect chickens
A - E
lymphoid leukosis
- B cells affected
- metastasize to produce tumors in organs
T/F: avian leukemia virus has a 4-month incubation period
TRUE
erythroblastosis
- immature erythrocytes affected
- gross pathological lesions (cherry red and enlarged)
myeloblastosis/myelocytomatosis
- granulocyte precursor affected
- similar presentation to erythroblastosis
how is avian leukosis/sarcoma virus transmitted
- through the egg (vertical)
- horizontal
- genetic transmission
what animals are most susceptible to lymphoid leukosis
congenitally infected
young chicks
Marek’s disease pathogenesis
- transforms T cells
- sexually immature chickens
- presents as paralysis and immunosuppression
avian reticuloendotheliosis pathogenesis
- transforms B and T cells
define neurolymphomatosis. what disease does this manifest in?
an abnormal accumulation of lymphocytes in the nerves resulting in paralysis
Marek’s disease
summarize the transmission of Marek’s in 4 steps
- respiratory infection
- T cell infection and altered migration pattern
- T cell accumulation in nerves and skin
- virus shed in infected skin cells
what avian diseases have vaccination control
- Marek’s disease
- IBDV
- CAV
describe the pathogenesis of Infectious bursal disease virus (IBDV)
- 3-6 week-old chicks infected via oral entry
- replicates in gut macrophages (enteric infection = diarrhea)
- primary viremia (spread to bursal lymph nodes and compromises immune system)
- secondary viremia (spread to kidneys and create immune complexes)