Lecture 26 - GI/Liver Bacteriology 4

Question 1

what is the habitat of Helicobacter

Answer 1

1. gastric mucosa
2. intestines
3. liver
4. bile

Question 2

what two ways are helicobacter transmitted

Answer 2

1. oral-oral
2. fecal-oral

Question 3

describe the pathogenesis of helicobacter in steps

Answer 3

1. attachment to epithelial cells through the mucosal layer
2. secretion of urease neutralizes gastric acid
3. recruitment of more bacteria
4. mucosal damage via gastric acid and damage by cytotoxins/ammonia

Question 4

describe helicobacter clinically in humans

Answer 4

• primary cause of gastric/duodenal ulcers
• cancer
• gnawing/burning when stomach is empty

Question 5

describe helicobacter clinically in animals

Answer 5

• asymptomatic to mild gastritis to cancer
• gastritis in pigs/cats/dogs

Question 6

how is helicobacter diagnosed

Answer 6

1. endoscopy
2. urease activity
3. culture
4. PCR

Question 7

T/F: treatment of helicobacter is controversial due to normality of asymptomatic signs and quick resistance development

Answer 7

TRUE

Question 8

how is helicobacter controlled in pigs

Answer 8

diets changed to consist of coarser ground feed