Lecture 25 - GI/Liver Bacteriology 3

Question 1

describe the characteristics of:

campylobacter

Answer 1

gram -
curved rod
aerobic (micro)

Question 2

describe the characteristics of:

helicobacter

Answer 2

gram -
helical/s-shaped
aerobic (micro)

Question 3

describe the characteristics of:

Lawsonia

Answer 3

gram -
curved rod
aerobic (micro)

Question 4

describe the characteristics of:

bracyspira

Answer 4

gram -
curved/spiral-shaped
aerotolerant (anaerobe)

Question 5

where is the habitat of Campylobacter

Answer 5

intestinal and genital tract of animals (ZOONOTIC)

Question 6

T/F: campylobacter is a thermophile, it needs 37-42 degrees to grow

Answer 6

TRUE

Question 7

what clinical signs does C. jejuni cause after infection

Answer 7

abortion in sheep
enteritis in dogs
avian hepatitis
enterocolitis in humans

Question 8

90% of human infections comes from what two campylobacter spp.

Answer 8

C. jejuni and C. coli

Question 9

describe campylobacter pathogenesis in 4 steps

Answer 9

1. adhere to the intestinal lining
2. invade cells
3. may replicate intracellularly
4. leaves cell

Question 10

what toxins are produced by campylobacter

Answer 10

LPS and CDT

Question 11

severity of campylobacter disease is dependent on what 4 factors

Answer 11

1. # of organisms
2. previous exposure
3. co-disease
4. environment/physical stress

Question 12

T/F: if there are no neutralizing antibodies against C. jejuni then clinical disease is worse

Answer 12

FALSE - no clinical disease due to no inflammation

Question 13

what species has no neutralizing antibodies against c. jejuni

Answer 13

chickens

Question 14

why is it difficult to confirm disease-causing campylobacter?

Answer 14

there are naturally occurring campylobacter in the GI tract

Question 15

what are the risk factors for campylobacter disease

Answer 15

1. age
2. immunosuppression
3. high-density housing

Question 16

T/F: campylobacter spp. in humans can be a reservoir of AMR

Answer 16

TRUE

Question 17

what testing is available for Campylobacter? Which is the best?

Answer 17

1. cytology (supportive not diagnostic)
2. PCR (best!!!)
3. fecal culture (variable results)

Question 18

T/F: tx of campylobacter involves routine use of antibiotics

Answer 18

FALSE - abx only in severe cases, normally supportive care

Question 19

how is campylobacter controlled/prevented

Answer 19

1. isolation of symptomatic animals
2. proper food handling
3. hand hygeine
4. sanitation