Lecture 11 - Respiratory Virology 1 Flashcards
what influenza type infects humans
B
what influenza type infects humans and pigs
C
what influenza type infects cattle and pigs
D
T/F: Influenza A infects all mammals
TRUE
what are the two envelope proteins of the flu
H and N
describe the makeup of the flu virus
8 segments of RNA “mini genes” enveloped by proteins
what is the target of influenza
respiratory epithelium
what 2 ways does the flu evolve
- antigenic drift (point mutation)
- antigenic shift (reassortment)
describe antigenic drift of the flu virus
mutations in envelope proteins allow escape from the immune system
describe antigenic shift of the flu virus
sudden reassortment from dual infection
H1N1
swine flu
swine to human transmission
T/F: pigs are known as the origin of interspecies transmission due to a specific receptor
FALSE - “mixing vessel” due to multiple receptors being present
what is the transmission of H1N1
aerosolized respiratory secretions and avian sheds in feces
describe the pathogenesis of H1N1 in swine and equine
- local resp. infection
- fever, cough, anorexia
- discharge
- bronchopneumonia
what are the different types of alveolar lesions created by the flu
- atelectasis (collapse)
- consolidation (inflamed)
H5N1
High-path bird flu