4.4.2 HPV

Question 1

What are the vaccination reccomendations for HPV?

Answer 1

Question 2

What is problematic about the test characteristics of the PAP smear?

Answer 2

Sensitivity, HPV testing is way more sensitive

Question 3

What makes Miles so unique?

Answer 3

His Pintrest account

Question 4

What races have the highest rates of cervical cancer?

Answer 4

Hispanic and black

Question 5

Which vaccine has the best effect on cervical cancer rate?

Answer 5

HPV9 vaccine (9-valent)

Question 6

Are most states meeting HPV vaccination protocols?

Answer 6

Not really

Question 7

Which HPVs cause anogenital warts?

Answer 7

HPV 6 and 11

Question 8

What are the two proteins that HPV produces that increase cancer and why?

Answer 8

E6: degrades P53, TLR9 activation

E7: Degrades Rb

Question 9

What part of the female anatomy is most susceptible to HPV infection?

Answer 9

Transformation zone

Question 10

What % of cancers have an uderlying infection?

Answer 10

17-18%

Question 11

Most risky HPV?

Answer 11

HPV 16!!!!

Question 12

At what rate, do sexually active college women contract HPV?

Answer 12

Question 13

What infections predispose to cancer? (3)

Answer 13

H. Pylori = stomach

HPV = cervix, etc

Viral hep = liver

Question 14

What is the cost burden of HPV?

Answer 14

6.6 Billion

Question 15

What are the two HPV capsid proteins?

Answer 15

L1 and L2

Question 16

What is the progression timeline b/t HPV infection and cervical cancer?

Answer 16