1.3.3 Male Reproductive Endocrinology Flashcards
Name three factors that stimulate GnRH release
Leptin, norepinephrine (NE), neuropeptide Y (NPY)
Where is the majority of estradiol produced? How?
Adipose; aromatization of testosterone
What does inhibin level correlate with?
total sperm count and testicular volume
index of spermatogenesis
What is the main function of inhibin B from sertoli cells?
Suppress FSH secretion from pituitary
ABP produced and released?
Produced by sertoli cells and released into the lumen of the seminiferous tubules
What are the three principal hormones produced by the gonads?
Testosterone and Estradiol (Leydig cells)
Inhibin B (Sertoli)
What is andropaus
![](https://s3.amazonaws.com/brainscape-prod/system/cm/211/323/528/a_image_thumb.png?1492015392)
Along with secondary sex characteristic development, what occurs during puberty?
Growth
What do sertoli cells release in the negative feedback loop on FSH?
Inhibin B
What factors inhibit the release of GnRH? (5)
GABA, dopamine (DA), IL-1, beta-endorphin, prolactin
How does gonadotrophins (LH and FSH) work?
Bind G protein receptors, activate AC, production of cAMP, activation of protein kinase A (PKA)
What does testosterone control?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/211/322/977/a_image_thumb.png?1492014823)
What is activin?
locally (pituitary) produced peptide that antagonizes inhibin B resulting in the stimulation of FSH release
What are the key steps in testerone synthesis and metabolism?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/211/321/743/a_image_thumb.png?1492013741)