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Reproduction and Sexuality > 3.4.3 Uterine Pathology > Flashcards

3.4.3 Uterine Pathology Flashcards

1
Q

What is this an image of?

A

Endometrial adenocarcinoma with squamous differentiation

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2
Q

What are the clinical features and treatment of endometrial carcinoma?

A
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3
Q

What is this an image of and what are the characteristics?

A
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4
Q

What are the characteristics of the Secretory phase?

A

Last 14 days

Progesterone

Secretions

Coiled glands

Edematous stroma

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5
Q

What is endometrial hyperplasia?

A

Increase in the number of glands relative to the stroma (crowded glands)

Clinical importance - common cause of abnormal bleeding and precursor lesion of the most common form of endometrial carcinoma

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6
Q

What are the covered parts?

A
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7
Q

What is this an image of?

A

Villo-glandular adenocarcinoma

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8
Q

What are is the pathogenesis and clinical features of endometriosis?

A
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9
Q

What is a leiomyoma?

A

Benign Smooth muscle tumor

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10
Q

What is the treatment of endometrial hyperplasia?

A

Hormonal - high dose progestins

Hysterectomy

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11
Q

Describe the progression of proliferative endometrium to Grade 1 uterine endometroid carcinoma.

A
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12
Q

How will the stroma appear in the secretory phase?

A

Stromal edema

Prominent arterioles

Predecidualization

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13
Q

What is adenomyosis?

A

Endometrial glands an stroma in the myometrium

Pathology - glands and stroma, Gross - red soft areas in the myometrium

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14
Q

What is this an image of?

A

Malignant Mixed Mullerian Tumor

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15
Q

What are the characteristics of leiomyosarcoma?

A
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16
Q

What are these images of?

A

Endometrial polyp w Complex hyperplasia

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17
Q

What is the difference between these?

A
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18
Q

What are these images of?

A

Leiomyosarcoma

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19
Q

What are these images of?

A

Low grade endometrial sarcoma

Left - desmin stain

Right - CD10 stain

20
Q

What are the common risk factors associated with endometrial andenocarcinoma?

A

Prolonged estrogen exposure

21
Q

What phase is this in? What is important to note?

A

This is in the secretory phase

There is stroma edema

22
Q

What are the basic characteristics of acute and chronic endometritis?

A

Acute - PMNs: Ascending infection, abortion, or instrumentation

Chronic - Plasma cells - IUD, PID, abortion

Clinically - bleeding and pelvic pain - self limiting

23
Q

What is this an image of?

A

MMMT

Left arrow - cartilage

Right - rhabdomyosarcoma

24
Q

What are the clinical features and treatment of Leiomyoma?

A

Clinical features - Depends on location, symptomatic, DUB, Mass, others

Treatment - Myometcomy, Hysterectomy, Laparoscopic uterine artery embolization or ligation in women who want to preserve fertility

25
Q

What are the covered parts and what are these?

A
26
Q

What are the pathological findings associated with endometriosis?

A

Red Blue areas (Mulberry Nodules)

Powder burns secondary to hemosiderin

Fibrous adhesions

Endometrial glands and stroma

Hemorrhage and fibrosis

27
Q

What are the histological characteristics of Endometrial polyps?

A

Endometrial glands, cysts and hyperplasia

Fibrous stroma

Thick-walled blood vessels

28
Q

How will glands appear in the secretory phase?

A

Subnuclear vacuoles

Supranuclear vacuoles

Intraluminal secretions

29
Q

How do you classify endometrial hyperplasia?

A
30
Q

What are these images of?

A

Low grade endometrial sarcoma

31
Q

What are the clinical features of endometrial hyperplasia?

A

Tumor, obesity, PCO, estrogen therapy

Uterine bleeding

32
Q

What are the gross and histological characteristics of endometrial adenocarcinoma?

A
33
Q

What are the characteristics of the proliferative phase?

A

First 14 days

Estrogen

Proliferation

Tubular Glands

Monomorphic Stroma

34
Q

What is this an image of?

A

adenomyosis

35
Q

What is this an image of?

A

Secretory adenocarcinoma

36
Q

What is the WHO classification of Endometrial hyperplasia?

A
37
Q

What are the covered parts?

A
38
Q

What are the HONDA risk factors?

A

H - Hormones

O - Obesity

N - Nulliparous

D - Diabetes

A - Aging

39
Q

What is this an image of?

A

Benign endometrial hyperplasia

Cystic hyperplasia

40
Q

What are the important findings in each of these images?

A

Left 2 - Sub and supra nuclear vacuoles

RIght - intraluminal secretions

41
Q

What are the difference between the type I and type II endometrial carcinoma?

A
42
Q

What is endometriosis?

A

Endometrial glands and stroma outside of the uterus

Can be in the ovaries, tubes or round ligaments

43
Q

How does the image on the left compare to the image on the right?

A

Left - proliferative

Right - secretory

44
Q

What is this an image of?

A

Leiomyosarcoma

45
Q

What are the covered parts?

A

Left - acute infection - PMNs

Rigt - chronic infection - plasma cells

Reproduction and Sexuality (58 decks)

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