3.1.3 Breast Histology and Physiology Flashcards

1
Q

What is this an image of?

A

TDLU atrophic ducts

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2
Q

What happens to the breast during pregnancy?

A
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3
Q

Describe the secretory function of mammary alveolar cells

A
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4
Q

What happens to the postmenopausal breast?

A
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5
Q

What happens to the breast after ovulation as a combined effect of estrogen and progesterone?

A

The number of acini per lobule increases

Vacuolization of epithelial cells

Marked intralobular stromal edema

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6
Q

What are the characteristics of Squamous metaplasia of lactiferous ducts (SMOLD)?

A

Not associated with lactation

Strong association with smoking

Squamous metaplasia of lactiferous ducts leads to keratin trapped within the duct and dilation leading to ruptur and an intense inflammatory response

Painful erythematous subareolar mass

Treated by surgical excision

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7
Q

What is this an image of?

A

Mammary duct ectasia

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8
Q

What is this an image of?

A

TDLU during pregnancy

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9
Q

What is the pathogenesis of Nonproliferative Fibrocystic changes?

A

Hormonal imbalances between estrogen and progesterone

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10
Q

What are the characteristics of intralobular stroma?

A

Loose, delicate myxomatous stroma

Hormonally responsive

Contains scattered lymphocytes

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11
Q

What is the most common presentation of breast cancer in the clinic?

A

Abnormal mammogram

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12
Q

What is this an image of?

A

Normal TDLU

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13
Q

What are the characteristics of nonproliferative fibrocystic changes in benign breast lesions?

A

Not a disease

Conferring no increased risk of developing carinoma

The single most common disorder of the breast

Palpable lumps, mammographic densities, calcifications and nipple discharges

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14
Q

What is this an image of?

A

Fat necrosis in the breast

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15
Q

What are the covered parts?

A
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16
Q

In women what happens to normal breast development at menarche?

A
17
Q

What is the histology associated with Nonproliferative Fibrocystic Changes?

A

Fibrosis - rupture of cysts leading to chronic inflammation and scarring fibrosis

Adenosis - Increase in the number of lobular units per lobule

18
Q

What are the characteristics of acute mastitis?

A

Almost always occurs during the lactation period

Staphylococcus aureus and streptococci

Unilateral, erythematous, painful abscess

Treated by antibiotics and complete drainage of milk

19
Q

When should women begin getting a mammogram every year?

A

Age 45-54 should get one every year

20
Q

What does actual lactation occur after birth?

A

Removal of progesterone inhibition on prolactin

Suckling leads to release of oxytocin and milk ejection by contraction of myoepithelial cells

21
Q

What are the characteristics of the terminal duct lobular unit (TLDU)?

A

Ducts and lobules are lined by an inner ductal epithelium and out myoepithelial layer

A basal lamina consisting of type IV collagen and laminin is present outside of the myoepithelial cell layer and serves to demarcate the breast TLDU from the surrounding stroma

22
Q

What is this an image of?

A

Apocrine metaplasia with intraluminal microcalcifications

Nonproliferative fibrocystic changes

23
Q

What is this an image of?

A

Lactational changes in the breast

24
Q

What are the characteristics of breast fat necrosis?

A
25
Q

What is this an image of?

A

Mammary duct ectasia

26
Q

What are the characteristics of the interlobular stroma?

A

Dense fibroconnective tissue admixed with adipose

27
Q

What is this an image of? What are the arrows pointing at?

A

Normal TLDU

28
Q

What is this an image of? What are the covered parts

A

NEED TO KNOW APOCRINE METAPLASIA

VERY HIGH YIELD

29
Q

What is the clinical presentation of Breast Disease?

A
30
Q

Rising levels of estrogen throughout pregnancy does what to prolactin?

A

Increases prolactin secretion and thus stimulates milk production

Milk production is inhibited by high levels of progesterone during pregnancy

31
Q

What is this an image of?

A

Fibrocystic changes - increased number of cysts

32
Q

What are the characteristics of Mammary duct ectasia?

A

Associated with older age (50s-60s)

Inspissation of breast secretions leads to dilation of ducts and periductal and interstitial chronic granulomatous inflammatory reaction

Thick, cheesy nipple secretion

33
Q

What is this an image of?

A

SMOLD

Squamous metaplasia