3.4.2 Reproductive Pharmacology Flashcards
What are the aromatase inhibitors?
competitive (anastrozole, letrozole)
Irreversible (exemestane, formestane)
What are the three SERMs?
Tamoxifen (antagonist in breast), clomiphene (antagonist in hypothalmus/pituitary), raloxifene (antagonist in ___)
What does the hypothalmus use to upregulates anterior pituitary production of LH/FSH?
GnRH
What are some of the anti-androgens?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/212/590/112/a_image_thumb.png?1493308317)
What are the uses of aromatase inhibitors?
Early/advanced breast carcinoma
Where is LH and FSH clinical pharmacology typically used?
Ovulation induction
Male infertility
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What are the different receptor agonists of estrogen?
Natural
Synthetic - Steriodal (ethinyl E2, mestronol, quinestrol) and Non-steriodal (Diethylstilbestrol, chlorotrianisene, methallenestrill)
In what medical condition is there a lack of release of GnRH from the hypothalmus?
Kallman Syndrome
Describe the release of GrRH
Pulsatile
When is GnRH clinical pharmacology used?
Progressive precocious puberty
Prostate cancer
Endometriosis
Assisted reproduction
Uterine leiomyomata (fibroids)
Male/female infertility
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What are the uses of estrogen agonists?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/212/588/638/a_image_thumb.png?1493307480)
What are the clinical toxicity effects of GnRH in females? males?
Females: symptoms of menopause, ovarian cysts (temporary), osteoporosis
Males: Hot flushes, sweats, edema, gynecomastia, osteoporosis
What are the two forms of progesterone and their functions?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/212/588/321/a_image_thumb.png?1493307116)
What are the 8 functions of estrogens?
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