2.2.2 Bladder and Penile Neoplasia Flashcards
What are the clinical features of squamous cell carcinoma of the penis?
What determines the prognosis of urothelial tumors?
What are the characteristics of Condyloma acuminatum?
Benign sexually transmitted tumor caused by HPV
Related to common wart
Occurs on moist mucocutaneous surface of the external genitals of either sex
HPV 6 is most common relation
What are the characteristics of low-grade papillary urothelial carcinomas?
Orderly appearance both architecturally and cytologically
Evenly spaced cohesive cells, with minimal but definitive nuclear atypia, infrequent mitosis
Good clinical course
What is this an image of?
Bowen disease carcinoma in situ of the penis
What is this an image of?
Squamous cell carcinoma of the penis
What is this an image of?
Low-grade papillary urothelial carcinoma
What is Bowen disease?
Subtype of CIS
What are the characteristics of urothelial papilloma?
What are the characteristics of invasive urothelial cancer?
What is this an image of?
Ulcerated lesion - bladder tumor
What are the characteristics of squamous cell carcinoma of the penis?
What is this an image of?
High grade invasive urothelial carcinoma
Most common age when bladder tumors arise?
Between 50 and 80
What is this an image of?
Condyloma acuminatum of the paenis
What are some of the symptoms of bladder tumors?
Painless hematuria
Frequency, urgency, and dysuria
High recurrent rate
What is the treatment of urothelial tumors?
What are the characteristics of High-grade papillary urothelial carcinoma?
Dyscohesive cells, with large hyperchromatic nuclei, frank anaplasia
Frequent mitotic figures, including atypical ones
Architecturally, disarray and loss of polarity
High incidence of invasion into the muscular layer
What is Bowenoid papulosis?
What type of bladder tumor is this?
Papillary tumor
What are the characteristics of Carcinoma in situ or flat urothelial carcinoma?
What is this an image of?
High-grade papillary urothelial carcinomas
What is this an image of?
Urothelial papilloma
What is this an image of?
Invasive urothelial carcinoma invading muscularis propria
What are some of the predisposing factors to bladder tumors?
Cigarette smoking
Aryl amines
Schistosoma haematobium
Analgesics
Cyclophosphamide
What are the 4 morphologic patterns of bladder tumors?
What is this an image of?
Condyloma acuminatum
What are the two distinct precursor lesions to Urinary bladder tumors?
Non-invasive papillary tumors
Flat non-invasive urothelial carcinoma
Describe the staging of bladder carcinoma
Ta - noninvasive, papillary
Tis - Carcinoma in situ
T1 - Lamina propria invasion
T2 - Muscularis propria invasion
T3a - Microscopic extra-vesicle invasion
T3b - Grossly apparent extra-vesicle invasion
T4 - Invades adjacent structures
What is this an image of?
Carcinoma in situ or flat urothelial carcinoma
