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Reproduction and Sexuality > 3.3.1 Benign Lesions of the Breasts > Flashcards

3.3.1 Benign Lesions of the Breasts Flashcards

1
Q

Which growth pattern of DCIS homegirl?

A

Noncomedocarcinoma

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2
Q

What this be?

A

Intraductal papilloma

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3
Q

What this be?

A

Comedo DCIS

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4
Q

What this be?

A

Epithelial hyperplasia w/o atypia

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5
Q

What are some of the different clinical presentations of breast carcinoma?

A

Pain, palpable mass, lumpiness, nipple discharge or skin change, screen mammography

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6
Q

Condition?

A

Lobular carcinoma is situ (LCIS)

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7
Q

What this be?

A

LCIS

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8
Q

Name this condition?

A

Papilloma

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9
Q

Name this gene

A

BRCA1

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10
Q

Condition?

A

DCIS

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11
Q

What this be?

A

Paget’s dz

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12
Q

Condition?

A

LCIS

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13
Q

Left? Right?

A

Left: Papillary DCIS

Right: Mircopapillary DCIS

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14
Q

Large duct papillomas are usually what? Small duct?

A

Large -> Solitary

Small -> Multiple

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15
Q

What are the 3 types of benign breast lesions?

A

Non-proliferative breast changes (fibrocystic)

Proliferative w/o atypia

Proliferative w/ atypia

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16
Q

What are some of the different hormonal influences that can increase risk of breast carcinoma?

A
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17
Q

What this be?

A

Sclerosing adenosis

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18
Q

Name this condition?

A

ADH

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19
Q

Name this condition?

A

Breast carcinoma

20
Q

What are two broad categories of risk factors for breast cancer?

A

Hormonal and genetic

21
Q

Where do all carcinomas arise?

A

terminal duct lobular unit (TDLU)

22
Q

Name this condition

A

Sclerosing adenosis

23
Q

What are some of the environmental factors associated with breast carcinoma?

A
24
Q

What are the diagnostic procedures for breast carcinoma?

A

Clincial exam

Radiology (mammography, US, MRI)

Core needle biopsy

25
Q

What this be?

A

Comedo DCIS

26
Q

What this be?

A

Epithelial hyperplasia w/o atypia

27
Q

What are the defining characteristics of epithelial hyperplasia?

A

more than two cell layers are present

florid, but architecturally and cytologically benign, hyperplasia (hyperplasia w/o atypia-usual ductal hyperplasia, UDH)

28
Q

What this be?

A

ALH

29
Q

What are three disorders that fall under proliferative breast dz w/o atypia?

A

Moderate or florid epithelial hyperplasia w/o atypia

Sclerosing adenosis/ complex sclerosing lesion

Papilloma

30
Q

What are the four different pathologies of breast carcinoma?

A
31
Q

What this be?

A

Sclerosing adenosis (complex sclerosing lesion)

32
Q

Condition?

A

Paget’s Dz of the Nipple (paget cells)

33
Q

Sporadic cases are breast cancer are generally associated with what? Hereditary cases?

A

Sporadic: Hormonal exposure

Hereditary: Germline mutations

34
Q

Left? Right?

A

Left: Cribiform DCIS

Right: Solid DCIS

35
Q

Left? Right?

A

Left: Paget dz

Right: Normal

36
Q

What are the two forms of proliferative breast dz w/ atypia?

A

Atypical ductal hyperplasia (ADH)

Atypical lobular hyperplasia (ALH)

37
Q

What is the racial predisposition to breast carcinoma?

A

White > AA > Asian > Hispanic

38
Q

What growth pattern of ductal carcinoma in situ?

A

Comedocarcinoma

39
Q

What this be?

A

Paget dz

40
Q

What is going on in proliferative breast dz w/o atypia?

A

Proliferation of ductal epithelium and/or stroma without cellular abnormalities

41
Q

What type of cancer bro?

A

Ductal carcinoma in situ

42
Q

How does the risk of invasive breast cancer increase with: nonproliferative fibrocystic change, proliferative breast dz w/o atypia, proliferative breast dz w/ atypia?

A

NP Fibro change: No increased risk

Prolif w/o atypia: 1.5-2X risk

Prolif w/ atypia: 4-5X risk

43
Q

What left be? What right be?

A

Left: ADH

Right: ALH

44
Q

Name this gene

A

BRCA2

45
Q

What this be?

A

Solid DCIS w/ microcalcifications

Reproduction and Sexuality (58 decks)

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