3.3.1 Benign Lesions of the Breasts Flashcards
Which growth pattern of DCIS homegirl?
Noncomedocarcinoma
What this be?
Intraductal papilloma
What this be?
Comedo DCIS
What this be?
Epithelial hyperplasia w/o atypia
What are some of the different clinical presentations of breast carcinoma?
Pain, palpable mass, lumpiness, nipple discharge or skin change, screen mammography
Condition?
Lobular carcinoma is situ (LCIS)
What this be?
LCIS
Name this condition?
Papilloma
Name this gene
BRCA1
Condition?
DCIS
What this be?
Paget’s dz
Condition?
LCIS
Left? Right?
Left: Papillary DCIS
Right: Mircopapillary DCIS
Large duct papillomas are usually what? Small duct?
Large -> Solitary
Small -> Multiple
What are the 3 types of benign breast lesions?
Non-proliferative breast changes (fibrocystic)
Proliferative w/o atypia
Proliferative w/ atypia
What are some of the different hormonal influences that can increase risk of breast carcinoma?
What this be?
Sclerosing adenosis
Name this condition?
ADH
Name this condition?
Breast carcinoma
What are two broad categories of risk factors for breast cancer?
Hormonal and genetic
Where do all carcinomas arise?
terminal duct lobular unit (TDLU)
Name this condition
Sclerosing adenosis
What are some of the environmental factors associated with breast carcinoma?
What are the diagnostic procedures for breast carcinoma?
Clincial exam
Radiology (mammography, US, MRI)
Core needle biopsy
What this be?
Comedo DCIS
What this be?
Epithelial hyperplasia w/o atypia
What are the defining characteristics of epithelial hyperplasia?
more than two cell layers are present
florid, but architecturally and cytologically benign, hyperplasia (hyperplasia w/o atypia-usual ductal hyperplasia, UDH)
What this be?
ALH
What are three disorders that fall under proliferative breast dz w/o atypia?
Moderate or florid epithelial hyperplasia w/o atypia
Sclerosing adenosis/ complex sclerosing lesion
Papilloma
What are the four different pathologies of breast carcinoma?
What this be?
Sclerosing adenosis (complex sclerosing lesion)
Condition?
Paget’s Dz of the Nipple (paget cells)
Sporadic cases are breast cancer are generally associated with what? Hereditary cases?
Sporadic: Hormonal exposure
Hereditary: Germline mutations
Left? Right?
Left: Cribiform DCIS
Right: Solid DCIS
Left? Right?
Left: Paget dz
Right: Normal
What are the two forms of proliferative breast dz w/ atypia?
Atypical ductal hyperplasia (ADH)
Atypical lobular hyperplasia (ALH)
What is the racial predisposition to breast carcinoma?
White > AA > Asian > Hispanic
What growth pattern of ductal carcinoma in situ?
Comedocarcinoma
What this be?
Paget dz
What is going on in proliferative breast dz w/o atypia?
Proliferation of ductal epithelium and/or stroma without cellular abnormalities
What type of cancer bro?
Ductal carcinoma in situ
How does the risk of invasive breast cancer increase with: nonproliferative fibrocystic change, proliferative breast dz w/o atypia, proliferative breast dz w/ atypia?
NP Fibro change: No increased risk
Prolif w/o atypia: 1.5-2X risk
Prolif w/ atypia: 4-5X risk
What left be? What right be?
Left: ADH
Right: ALH
Name this gene
BRCA2
What this be?
Solid DCIS w/ microcalcifications
