4.1.1 Reproductive and Breast Malignancies

Question 1

What system is used to classify tumors?

Answer 1

TNM staging

Question 2

What is treatment goals for metastatic prostate cancer?

Answer 2

Incurable - Survival measured in years

Question 3

When would systemic therapy included in the treatment of breast cancer?

Answer 3

Metastatic dz

Question 4

2nd most common cause of cancer morbidity and mortality in women in developing countries?

Answer 4

Cervical cancer

Question 5

Why is cervical cancer less frequenct now?

Answer 5

PAP smears

Question 6

How do you treat patients with seminoma?

Answer 6

Surgery followed by adjuvant chemotherapy or radiation

Question 7

What are the signs of ovarian cancer?

Answer 7

POST MENOPAUSAL PALPABLE OVARY

Question 8

Where can chemotherapy be given for ovarian therapy?

Answer 8

Platinum compounds - Intraperitoneal chemotherapy because spread is common there

Question 9

What is the therpeutic effort for germ cell tumors?

Answer 9

Therapeutic effort is cure even in metastatic disease

Question 10

What is the goal for a seminoma?

Answer 10

CURE

Treatment with radiation therapy

Question 11

Patients with nonseminomatous germ cell tumor of the testes receive what?

Answer 11

Adjuvant chemotherapy (CISPLATIN)

Question 12

What is the initial therapy for germ cell tumor of the testes?

Answer 12

Inguinal orchiectomy

Question 13

What are some of the different therapies for breast cancer?

Answer 13

Lumpectomy, adriamycin and cytoxan times four, taxotere with herceptin, XRT, aromatase inhibitor, bisphosphonate

Question 14

Why would a patient with Prostate cancer get an orchiectomy?

Answer 14

Decreases the testerone - keeps prostate size down

Question 15

What is Sipuleucel T?

Answer 15

First line immunotherapy approved for prostate cancer

Question 16

What are the serum markers for non-seminomatous tumor?

Answer 16

Beta hCG - produced from syncytiotrophoblast

AFP - Produced in the liver, yolk sac and GI tract

Question 17

What emprises the performance status?

Answer 17

Question 18

What are the risk factors of cervical cancers?

Answer 18

STIs

History of vulvar or vaginal squamous

HPV

Smoking

Immunocompromised states

Question 19

How has the incidence of cervical cancer changed over the past 50 years in developed countries?

Answer 19

75% decrease

Question 20

Response rate?

Answer 20

CR + PR / Total diagnosed

Question 21

What is the primary management of ovarian cancer?

Answer 21

SURGERY

Question 22

What is circumscribed in red?

Answer 22

Liver metastases

Question 24

What is the chemotherapy for cervical cancer?

Answer 24

Cisplatinum

(Avastin is a newer option)

Question 25

What is the primary treatment of breast cancer?

Answer 25

Lumpectomy or Mastectomy (ALND or SLN)

Question 26

What are indicators of good prognosis?

Answer 26

Well differentiated, ER and PR positive

Question 27

Who should be on the team of a breast cancer patient?

Answer 27

Surgeon, oncologist, and radiation therapist

Question 28

What is one of the treatments of prostate cancer?

Answer 28

androgen deprivation

Question 29

What is the number one side effect of aromatase inhibitors?

Answer 29

Osteoporosis

Question 30

What is the most common cause of gynecological cancer death?

Answer 30

Cervical cancer

Question 31

Globally, what is the most common type of cancer and cause of cancer death?

Answer 31

Breast Cancer

Question 32

Where is a common place for prostate cancer to spread?

Answer 32

To the lower vertebrae

Question 33

What are the different reproductive malignancies?

Answer 33

Breast, cervical, ovarian, testes, and prostate

Question 34

What is overall survival?

Answer 34

Survival from date of diagnosis until death

Question 35

For metastatic cervical dz, what is treatment?

Answer 35

Palliative

Question 36

What is partial remission?

Answer 36

30% reduction, has changed over years