Wound Management and Topical Antibacterial Agents Flashcards
Are Antiseptics necessary with wound management and why?
NO - impede wound healing
Antibiotics are reserved for what types of wounds?
Clinically infected wounds
Poor _______ = worse outcomes
Poor glycemic (glucose) control = worse outcomes
What is Wound Debridement?
Removing dead tissue to promote healing
Wound Debridement involves what 2 changes to the wound?
- Decreased protease production
- Conservation of local resources needed for healing
4 types of Wound Debridement?
- Low pressure irrigation with saline
- Surgical
- Enzymatic
- Biological
Most common wound debridement?
Low pressure irrigation with saline
Surgical debridement is good for?
Removing large areas of dead tissue
Maggot therapy is a type of?
Biological debridement
What is Becaplermin?
Platelet - derived growth factor that promotes cell proliferation and angiogenesis
What is the only agent approved for treatment of chronic diabetic foot ulcers?
Becaplermin
What is a platelet-derived growth factor that promotes cell proliferation and angiogenesis?
Becaplermin
Becaplermin is great at increasing tissue healing. What is bad about it?
Black box warning for MALIGNANCY
- > 3 tubes used = 4X increased risk
With wound dressings, how should wound be kept?
Moist and not exposed to air
With wound dressing, what is used for the debridement stage?
Hydrogels
With wound dressing, what is used for the granulation stage?
Foam and low-adherence dressing
With wound dressing, what is used for the epithelialization stage?
Hydrocolloid and low-adherence dressing
What are 3 topical Antibacterial agents?
Bacitracin
Neomycin
Polymixin B
What are 3 topical Antibacterial agents?
Bacitracin
Neomycin
Polymixin B
MOA for Bacitracin
Inhibits bacterial cell wall synthesis
Bacitracin treats Gram ____ bacteria
(+)
MOA for Neomycin
Inhibits protein synthesis
Neomycin treats Gram ____ bacteria
(-)
MOA for Polymixin B
Alters permeability and damages bacterial cytoplasmic membrane
Polymixin B treats Gram ____ bacteria
(-)
This topical Antibacterial agent inhibits bacterial cell wall synthesis
Bacitracin
This topical Antibacterial agent inhibits bacterial protein synthesis
Neomycin
This topical Antibacterial agent damages bacterial cytoplasmic membrane
Polymixin B
What 2 topical Antibacterial agents can cause allergic contact dermatitis?
Bacitracin
Neomycin
Adverse side effects of Bacitracin and Neomycin
Allergic contact dermatitis
