Wound Management and Topical Antibacterial Agents

Question 1

Are Antiseptics necessary with wound management and why?

Answer 1

NO - impede wound healing

Question 2

Antibiotics are reserved for what types of wounds?

Answer 2

Clinically infected wounds

Question 3

Poor _______ = worse outcomes

Answer 3

Poor glycemic (glucose) control = worse outcomes

Question 4

What is Wound Debridement?

Answer 4

Removing dead tissue to promote healing

Question 5

Wound Debridement involves what 2 changes to the wound?

Answer 5

• Decreased protease production

- Conservation of local resources needed for healing

Question 6

4 types of Wound Debridement?

Answer 6

1. Low pressure irrigation with saline
2. Surgical
3. Enzymatic
4. Biological

Question 7

Most common wound debridement?

Answer 7

Low pressure irrigation with saline

Question 8

Surgical debridement is good for?

Answer 8

Removing large areas of dead tissue

Question 9

Maggot therapy is a type of?

Answer 9

Biological debridement

Question 10

What is Becaplermin?

Answer 10

Platelet - derived growth factor that promotes cell proliferation and angiogenesis

Question 11

What is the only agent approved for treatment of chronic diabetic foot ulcers?

Answer 11

Becaplermin

Question 12

What is a platelet-derived growth factor that promotes cell proliferation and angiogenesis?

Answer 12

Becaplermin

Question 13

Becaplermin is great at increasing tissue healing. What is bad about it?

Answer 13

Black box warning for MALIGNANCY

- > 3 tubes used = 4X increased risk

Question 14

With wound dressings, how should wound be kept?

Answer 14

Moist and not exposed to air

Question 15

With wound dressing, what is used for the debridement stage?

Answer 15

Hydrogels

Question 16

With wound dressing, what is used for the granulation stage?

Answer 16

Foam and low-adherence dressing

Question 17

With wound dressing, what is used for the epithelialization stage?

Answer 17

Hydrocolloid and low-adherence dressing

Question 18

What are 3 topical Antibacterial agents?

Answer 18

Bacitracin
Neomycin
Polymixin B

Question 19

What are 3 topical Antibacterial agents?

Answer 19

Bacitracin
Neomycin
Polymixin B

Question 20

MOA for Bacitracin

Answer 20

Inhibits bacterial cell wall synthesis

Question 21

Bacitracin treats Gram ____ bacteria

Answer 21

(+)

Question 22

MOA for Neomycin

Answer 22

Inhibits protein synthesis

Question 23

Neomycin treats Gram ____ bacteria

Answer 23

(-)

Question 24

MOA for Polymixin B

Answer 24

Alters permeability and damages bacterial cytoplasmic membrane

Question 25

Polymixin B treats Gram ____ bacteria

Answer 25

(-)

Question 26

This topical Antibacterial agent inhibits bacterial cell wall synthesis

Answer 26

Bacitracin

Question 27

This topical Antibacterial agent inhibits bacterial protein synthesis

Answer 27

Neomycin

Question 28

This topical Antibacterial agent damages bacterial cytoplasmic membrane

Answer 28

Polymixin B

Question 29

What 2 topical Antibacterial agents can cause allergic contact dermatitis?

Answer 29

Bacitracin

Neomycin

Question 30

Adverse side effects of Bacitracin and Neomycin

Answer 30

Allergic contact dermatitis