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SBL > Benign Epithelial Tumors > Flashcards

Benign Epithelial Tumors Flashcards

1
Q

Who gets Seborrheic Keratoses and how do they arise?

A

Middle age/older adults

- Arise SPONTANEOUSLY

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2
Q

What do Seborrheic Keratoses look like?

A

Tan-brown, round, waxy papules with granular surface

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3
Q

Tan-brown, round, waxy papules with a granular surface

A

Seborrheic Keratoses

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4
Q

Seborrheic Keratoses have pore-like ostia impacted with?

A

Keratin

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5
Q

Seborrheic Keratoses involve ______ that can form horn cysts

A

Hyperkeratosis

- Keratin filled cysts

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6
Q

Seborrheic Keratoses have activating mutations in?

A

FGFR-3

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7
Q

Dermatosis Papulosa Nigra

A

Black people with multiple small lesions on face

- (Seborrheic Keratoses)

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8
Q

Black people with multiple small lesions on face

A

Dermatosis Papulosa Nigra

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9
Q

Dermatosis Papulosa Nigra is a type of?

A

Seborrheic Keratoses

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10
Q

Horn cysts are seen with?

A

Seborrheic Keratoses

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11
Q

Leser-trelat syndrome

A
  • paraneoplastic syndrome

= GI carcinomas cause sudden appearance of many seborrheic keratoses

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12
Q

What is a paraneoplastic syndrome that involves the sudden appearance of many seborrheic keratoses?

A

Leser-trelat syndrome

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13
Q

Leser-trelat syndrome involves the appearance of many sebborheic keratoses from what carcinoma?

A

GI carcinomas

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14
Q

Acanthosis Nigricans

A

Thickened, hyperpigmented skin with velvet texture

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15
Q

Thickened, hyperpigmented skin with velvet texture

A

Acanthosis Nigricans

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16
Q

Where does Acanthosis Nigricans often develop?

A

Flexural areas or where the skin rubs together (intertriginous)

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17
Q

The majority of the cases of Acanthosis Nigricans are associated with what conditions?

A

Obesity and Diabetes

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18
Q

If Acanthosis Nigricans is not due to obesity/diabetes, what is likely causing it?

A

GI Adenocarcinomas releasing growth factors

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19
Q

The familial form of Acanthosis Nigricans has increased growth factor signaling at?

A

FGFR-3

20
Q

Obesity/Diabetes related Acanthosis Nigricans has increased growth factor signaling at?

A

IGFR-1

21
Q

Numerous repeating peaks and valleys on a histo image could indicate?

A

Acanthosis Nigricans

22
Q

What conditions are associated with activating mutations in FGFR-3?

A 
Seborrheic Keratoses
Acanthosis Nigricans (also IGFR-1)
23
Q

Other names for Fibroepithelial polyps?

A

Skin tags

Acrochordon

24
Q

Acrochordon/skin tags

A

Fibroepithelial polyps

25
Q

Where do Fibroepithelial polyps arise?

A

Areas where skin rubs together, face, neck, trunk

26
Q

What 3 conditions are Fibroepithelial polyps associated with?

A

Obesity
Diabetes
Intestinal polyposis

27
Q

What do Fibroepithelial polyps (skin tags) look like?

A

Flesh colored, soft, attached by slender stalk

28
Q

Flesh colored, soft, attached by slender stalk

A

Fibroepithelial polyps

29
Q

Fibroepithelial polyps are attached by?

A

Slender stalk

30
Q

How can Fibroepithelial polyps be removed?

A

Torsion

– Causes ischemic necrosis of stalk

31
Q

Epithelial or Follicular Inclusion Cyst is known as?

A

Wen

32
Q

Invagination and cystic expansion of epidermis/hair follicle

A

Wen

epithelial or follicular inclusion cyst

33
Q

Epithelial or Follicular Inclusion Cyst (Wen)

A

Invagination and cystic expansion of epidermis/hair follicle

34
Q

If a Wen ruptures, what will spill into the dermis?

A

Keratin

35
Q

If a Wen ruptures and Keratin spills into the dermis, what will result?

A

Granulomatous inflammatory response and PAIN

36
Q

A granulomatous inflammatory response with pain likely means?

A

A Wen ruptured

epithelial or follicular inclusion cyst

37
Q

Adnexal (appendage) Tumors

A

Neoplasms arising from cutaneous appendages

38
Q

Cowden syndrome is an appendage tumor. It involves multiple?

A

Multiple trichelemommas (hair follicles)

39
Q

Multiple trichelemommas involved are seen in what syndrome?

A

Cowden syndrome

40
Q

Cowden syndrome involves loss of function of?

A

PTEN

41
Q

Cowden syndrome is at increased risk for what 2 cancers?

A

Endometrial cancer

Breast cancer

42
Q

Cylindroma is an appendage tumor. It involves?

A

Ductal differentiaion of scalp or forehead

43
Q

Cylindroma involves what type of growth?

A

Hat like - turban tumor

44
Q

Turban tumors on the head are seen with?

A

Cylindromas

45
Q

What tumor suppressor gene is involved with Cylindromas?

A

CYLD

46
Q

Muir-Torre syndrome

A

Internal malignancies

- DNA mismatch repair

47
Q

Sebaceous adenoma appendage tumor

A

Muir-Torre Syndrome = internal malignancies

- DNA mismatch repair

SBL (48 decks)

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