Benign Epithelial Tumors

Question 1

Who gets Seborrheic Keratoses and how do they arise?

Answer 1

Middle age/older adults

- Arise SPONTANEOUSLY

Question 2

What do Seborrheic Keratoses look like?

Answer 2

Tan-brown, round, waxy papules with granular surface

Question 3

Tan-brown, round, waxy papules with a granular surface

Answer 3

Seborrheic Keratoses

Question 4

Seborrheic Keratoses have pore-like ostia impacted with?

Answer 4

Keratin

Question 5

Seborrheic Keratoses involve ______ that can form horn cysts

Answer 5

Hyperkeratosis

- Keratin filled cysts

Question 6

Seborrheic Keratoses have activating mutations in?

Answer 6

FGFR-3

Question 7

Dermatosis Papulosa Nigra

Answer 7

Black people with multiple small lesions on face

- (Seborrheic Keratoses)

Question 8

Black people with multiple small lesions on face

Answer 8

Dermatosis Papulosa Nigra

Question 9

Dermatosis Papulosa Nigra is a type of?

Answer 9

Seborrheic Keratoses

Question 10

Horn cysts are seen with?

Answer 10

Seborrheic Keratoses

Question 11

Leser-trelat syndrome

Answer 11

• paraneoplastic syndrome

= GI carcinomas cause sudden appearance of many seborrheic keratoses

Question 12

What is a paraneoplastic syndrome that involves the sudden appearance of many seborrheic keratoses?

Answer 12

Leser-trelat syndrome

Question 13

Leser-trelat syndrome involves the appearance of many sebborheic keratoses from what carcinoma?

Answer 13

GI carcinomas

Question 14

Acanthosis Nigricans

Answer 14

Thickened, hyperpigmented skin with velvet texture

Question 15

Thickened, hyperpigmented skin with velvet texture

Answer 15

Acanthosis Nigricans

Question 16

Where does Acanthosis Nigricans often develop?

Answer 16

Flexural areas or where the skin rubs together (intertriginous)

Question 17

The majority of the cases of Acanthosis Nigricans are associated with what conditions?

Answer 17

Obesity and Diabetes

Question 18

If Acanthosis Nigricans is not due to obesity/diabetes, what is likely causing it?

Answer 18

GI Adenocarcinomas releasing growth factors

Question 19

The familial form of Acanthosis Nigricans has increased growth factor signaling at?

Answer 19

FGFR-3

Question 20

Obesity/Diabetes related Acanthosis Nigricans has increased growth factor signaling at?

Answer 20

IGFR-1

Question 21

Numerous repeating peaks and valleys on a histo image could indicate?

Answer 21

Acanthosis Nigricans

Question 22

What conditions are associated with activating mutations in FGFR-3?

Answer 22

Seborrheic Keratoses
Acanthosis Nigricans (also IGFR-1)

Question 23

Other names for Fibroepithelial polyps?

Answer 23

Skin tags

Acrochordon

Question 24

Acrochordon/skin tags

Answer 24

Fibroepithelial polyps

Question 25

Where do Fibroepithelial polyps arise?

Answer 25

Areas where skin rubs together, face, neck, trunk

Question 26

What 3 conditions are Fibroepithelial polyps associated with?

Answer 26

Obesity Diabetes Intestinal polyposis

Question 27

What do Fibroepithelial polyps (skin tags) look like?

Answer 27

Flesh colored, soft, attached by slender stalk

Question 28

Flesh colored, soft, attached by slender stalk

Answer 28

Fibroepithelial polyps

Question 29

Fibroepithelial polyps are attached by?

Answer 29

Slender stalk

Question 30

How can Fibroepithelial polyps be removed?

Answer 30

Torsion | -- Causes ischemic necrosis of stalk

Question 31

Epithelial or Follicular Inclusion Cyst is known as?

Answer 31

Wen

Question 32

Invagination and cystic expansion of epidermis/hair follicle

Answer 32

Wen | epithelial or follicular inclusion cyst

Question 33

Epithelial or Follicular Inclusion Cyst (Wen)

Answer 33

Invagination and cystic expansion of epidermis/hair follicle

Question 34

If a Wen ruptures, what will spill into the dermis?

Answer 34

Keratin

Question 35

If a Wen ruptures and Keratin spills into the dermis, what will result?

Answer 35

Granulomatous inflammatory response and PAIN

Question 36

A granulomatous inflammatory response with pain likely means?

Answer 36

A Wen ruptured | epithelial or follicular inclusion cyst

Question 37

Adnexal (appendage) Tumors

Answer 37

Neoplasms arising from cutaneous appendages

Question 38

Cowden syndrome is an appendage tumor. It involves multiple?

Answer 38

Multiple trichelemommas (hair follicles)

Question 39

Multiple trichelemommas involved are seen in what syndrome?

Answer 39

Cowden syndrome

Question 40

Cowden syndrome involves loss of function of?

Answer 40

PTEN

Question 41

Cowden syndrome is at increased risk for what 2 cancers?

Answer 41

Endometrial cancer | Breast cancer

Question 42

Cylindroma is an appendage tumor. It involves?

Answer 42

Ductal differentiaion of scalp or forehead

Question 43

Cylindroma involves what type of growth?

Answer 43

Hat like - turban tumor

Question 44

Turban tumors on the head are seen with?

Answer 44

Cylindromas

Question 45

What tumor suppressor gene is involved with Cylindromas?

Answer 45

CYLD

Question 46

Muir-Torre syndrome

Answer 46

Internal malignancies | - DNA mismatch repair

Question 47

Sebaceous adenoma appendage tumor

Answer 47

Muir-Torre Syndrome = internal malignancies | - DNA mismatch repair