Benign Epithelial Tumors Flashcards
Who gets Seborrheic Keratoses and how do they arise?
Middle age/older adults
- Arise SPONTANEOUSLY
What do Seborrheic Keratoses look like?
Tan-brown, round, waxy papules with granular surface
Tan-brown, round, waxy papules with a granular surface
Seborrheic Keratoses
Seborrheic Keratoses have pore-like ostia impacted with?
Keratin
Seborrheic Keratoses involve ______ that can form horn cysts
Hyperkeratosis
- Keratin filled cysts
Seborrheic Keratoses have activating mutations in?
FGFR-3
Dermatosis Papulosa Nigra
Black people with multiple small lesions on face
- (Seborrheic Keratoses)
Black people with multiple small lesions on face
Dermatosis Papulosa Nigra
Dermatosis Papulosa Nigra is a type of?
Seborrheic Keratoses
Horn cysts are seen with?
Seborrheic Keratoses
Leser-trelat syndrome
- paraneoplastic syndrome
= GI carcinomas cause sudden appearance of many seborrheic keratoses
What is a paraneoplastic syndrome that involves the sudden appearance of many seborrheic keratoses?
Leser-trelat syndrome
Leser-trelat syndrome involves the appearance of many sebborheic keratoses from what carcinoma?
GI carcinomas
Acanthosis Nigricans
Thickened, hyperpigmented skin with velvet texture
Thickened, hyperpigmented skin with velvet texture
Acanthosis Nigricans
Where does Acanthosis Nigricans often develop?
Flexural areas or where the skin rubs together (intertriginous)
The majority of the cases of Acanthosis Nigricans are associated with what conditions?
Obesity and Diabetes
If Acanthosis Nigricans is not due to obesity/diabetes, what is likely causing it?
GI Adenocarcinomas releasing growth factors
The familial form of Acanthosis Nigricans has increased growth factor signaling at?
FGFR-3
Obesity/Diabetes related Acanthosis Nigricans has increased growth factor signaling at?
IGFR-1
Numerous repeating peaks and valleys on a histo image could indicate?
Acanthosis Nigricans
What conditions are associated with activating mutations in FGFR-3?
Seborrheic Keratoses Acanthosis Nigricans (also IGFR-1)
Other names for Fibroepithelial polyps?
Skin tags
Acrochordon
Acrochordon/skin tags
Fibroepithelial polyps
Where do Fibroepithelial polyps arise?
Areas where skin rubs together, face, neck, trunk
What 3 conditions are Fibroepithelial polyps associated with?
Obesity
Diabetes
Intestinal polyposis
What do Fibroepithelial polyps (skin tags) look like?
Flesh colored, soft, attached by slender stalk
Flesh colored, soft, attached by slender stalk
Fibroepithelial polyps
Fibroepithelial polyps are attached by?
Slender stalk
How can Fibroepithelial polyps be removed?
Torsion
– Causes ischemic necrosis of stalk
Epithelial or Follicular Inclusion Cyst is known as?
Wen
Invagination and cystic expansion of epidermis/hair follicle
Wen
epithelial or follicular inclusion cyst
Epithelial or Follicular Inclusion Cyst (Wen)
Invagination and cystic expansion of epidermis/hair follicle
If a Wen ruptures, what will spill into the dermis?
Keratin
If a Wen ruptures and Keratin spills into the dermis, what will result?
Granulomatous inflammatory response and PAIN
A granulomatous inflammatory response with pain likely means?
A Wen ruptured
epithelial or follicular inclusion cyst
Adnexal (appendage) Tumors
Neoplasms arising from cutaneous appendages
Cowden syndrome is an appendage tumor. It involves multiple?
Multiple trichelemommas (hair follicles)
Multiple trichelemommas involved are seen in what syndrome?
Cowden syndrome
Cowden syndrome involves loss of function of?
PTEN
Cowden syndrome is at increased risk for what 2 cancers?
Endometrial cancer
Breast cancer
Cylindroma is an appendage tumor. It involves?
Ductal differentiaion of scalp or forehead
Cylindroma involves what type of growth?
Hat like - turban tumor
Turban tumors on the head are seen with?
Cylindromas
What tumor suppressor gene is involved with Cylindromas?
CYLD
Muir-Torre syndrome
Internal malignancies
- DNA mismatch repair
Sebaceous adenoma appendage tumor
Muir-Torre Syndrome = internal malignancies
- DNA mismatch repair
