HIV Pharmacology

Question 1

Describe the life cycle of HIV

Answer 1

• HIV binds and enters the host cell
• HIV uses reverse transcriptase to create DNA
• HIV uses integrase to insert DNA into host genome
• HIV then creates viral proteins and a mature HIV

Question 2

Describe the life cycle of HIV

Answer 2

• HIV binds and enters the host cell
• HIV uses reverse transcriptase to create DNA
• HIV uses integrase to insert DNA into host genome
• HIV then creates viral proteins and a mature HIV

Question 3

Fusion entry inhibitors inhibit?

Answer 3

Binding of HIV to the host cell

Question 4

Receptor entry inhibitors inhibit?

Answer 4

Chemokine and CD4 receptors on the host cell

Question 5

NRTI

Answer 5

Nucleoside Reverse Transcriptase inhibitors

Question 6

NRTIs do what?

Answer 6

Inhibit incorporation of native nucleotides and terminate elongation of DNA

Question 7

Inhibit incorporation of native nucleotides and terminate elongation of DNA

Answer 7

NRTIs

Question 8

NNRTI

Answer 8

Non-Nucleoside Reverse Transcriptase inhibitors

Question 9

INSTI

Answer 9

Integrase strand transfer inhibitors

Question 10

PI

Answer 10

Protease inhibitors

Question 11

PIs inhibit?

Answer 11

Maturation of the created HIV

Question 12

ART prevents infection of?

Answer 12

Susceptible cells

Question 13

ART does NOT?

Answer 13

Eradicate the virus from already infected cells

Question 14

ART usually begins with?

Answer 14

2 NRTIs

- each targeting a different base

Question 15

ART usually begins with?

Answer 15

2 NRTIs

- each targeting a different base

Question 16

ART =

Answer 16

2 NRTIs + 1 other agent

Question 17

ART =

Answer 17

2 NRTIs + 1 other agent

Question 18

ART experienced

Answer 18

HIV acquired in first decade of life

Question 19

ART naive

Answer 19

HIV acquired in second decade of life

Question 20

HIV acquired in first decade of life

Answer 20

HIV experienced